Abnormalities in Electroencephalographic Microstates Among Adolescents With First Episode Major Depressive Disorder
Background: Recent studies have reported changes in the electroencephalograms (EEG) of patients with major depressive disorder (MDD). However, little research has explored EEG differences between adolescents with MDD and healthy controls, particularly EEG microstates differences. The aim of the curr...
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.775156/full |
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| author | Yuqiong He Qianting Yu Tingyu Yang Yaru Zhang Kun Zhang Xingyue Jin Shuxian Wu Xueping Gao Xueping Gao Chunxiang Huang Chunxiang Huang Xilong Cui Xilong Cui Xuerong Luo Xuerong Luo |
| author_facet | Yuqiong He Qianting Yu Tingyu Yang Yaru Zhang Kun Zhang Xingyue Jin Shuxian Wu Xueping Gao Xueping Gao Chunxiang Huang Chunxiang Huang Xilong Cui Xilong Cui Xuerong Luo Xuerong Luo |
| author_sort | Yuqiong He |
| collection | DOAJ |
| description | Background: Recent studies have reported changes in the electroencephalograms (EEG) of patients with major depressive disorder (MDD). However, little research has explored EEG differences between adolescents with MDD and healthy controls, particularly EEG microstates differences. The aim of the current study was to characterize EEG microstate activity in adolescents with MDD and healthy controls (HCs).Methods: A total of 35 adolescents with MDD and 35 HCs were recruited in this study. The depressive symptoms were assessed by Hamilton Depression Scale (HAMD) and Children's Depression Inventory (CDI), and the anxiety symptoms were assessed by Chinese version of DSM-5 Level 2-Anxiety-Child scale. A 64-channel EEG was recorded for 5 min (eye closed, resting-state) and analyzed using microstate analysis. Microstate properties were compared between groups and correlated with patients' depression scores.Results: We found increased occurrence and contribution of microstate B in MDD patients compared to HCs, and decreased occurrence and contribution of microstate D in MDD patients compared to HCs. While no significant correlation between depression severity (HAMD score) and the microstate metrics (occurrence and contribution of microstate B and D) differing between MDD adolescents and HCs was found.Conclusions: Adolescents with MDD showed microstate B and microstate D changes. The obtained results may deepen our understanding of dynamic EEG changes among adolescents with MDD and provide some evidence of changes in brain development in adolescents with MDD. |
| first_indexed | 2024-12-23T13:45:33Z |
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| id | doaj.art-44c185243cba43d5af113bccd6847162 |
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| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-23T13:45:33Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-44c185243cba43d5af113bccd68471622022-12-21T17:44:44ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-12-011210.3389/fpsyt.2021.775156775156Abnormalities in Electroencephalographic Microstates Among Adolescents With First Episode Major Depressive DisorderYuqiong He0Qianting Yu1Tingyu Yang2Yaru Zhang3Kun Zhang4Xingyue Jin5Shuxian Wu6Xueping Gao7Xueping Gao8Chunxiang Huang9Chunxiang Huang10Xilong Cui11Xilong Cui12Xuerong Luo13Xuerong Luo14National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaAutism Center of the Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaAutism Center of the Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaAutism Center of the Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaAutism Center of the Second Xiangya Hospital, Central South University, Changsha, ChinaBackground: Recent studies have reported changes in the electroencephalograms (EEG) of patients with major depressive disorder (MDD). However, little research has explored EEG differences between adolescents with MDD and healthy controls, particularly EEG microstates differences. The aim of the current study was to characterize EEG microstate activity in adolescents with MDD and healthy controls (HCs).Methods: A total of 35 adolescents with MDD and 35 HCs were recruited in this study. The depressive symptoms were assessed by Hamilton Depression Scale (HAMD) and Children's Depression Inventory (CDI), and the anxiety symptoms were assessed by Chinese version of DSM-5 Level 2-Anxiety-Child scale. A 64-channel EEG was recorded for 5 min (eye closed, resting-state) and analyzed using microstate analysis. Microstate properties were compared between groups and correlated with patients' depression scores.Results: We found increased occurrence and contribution of microstate B in MDD patients compared to HCs, and decreased occurrence and contribution of microstate D in MDD patients compared to HCs. While no significant correlation between depression severity (HAMD score) and the microstate metrics (occurrence and contribution of microstate B and D) differing between MDD adolescents and HCs was found.Conclusions: Adolescents with MDD showed microstate B and microstate D changes. The obtained results may deepen our understanding of dynamic EEG changes among adolescents with MDD and provide some evidence of changes in brain development in adolescents with MDD.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.775156/fulladolescentsmajor depressive disorderEEG resting stateEEG microstatefirst-episode depression |
| spellingShingle | Yuqiong He Qianting Yu Tingyu Yang Yaru Zhang Kun Zhang Xingyue Jin Shuxian Wu Xueping Gao Xueping Gao Chunxiang Huang Chunxiang Huang Xilong Cui Xilong Cui Xuerong Luo Xuerong Luo Abnormalities in Electroencephalographic Microstates Among Adolescents With First Episode Major Depressive Disorder Frontiers in Psychiatry adolescents major depressive disorder EEG resting state EEG microstate first-episode depression |
| title | Abnormalities in Electroencephalographic Microstates Among Adolescents With First Episode Major Depressive Disorder |
| title_full | Abnormalities in Electroencephalographic Microstates Among Adolescents With First Episode Major Depressive Disorder |
| title_fullStr | Abnormalities in Electroencephalographic Microstates Among Adolescents With First Episode Major Depressive Disorder |
| title_full_unstemmed | Abnormalities in Electroencephalographic Microstates Among Adolescents With First Episode Major Depressive Disorder |
| title_short | Abnormalities in Electroencephalographic Microstates Among Adolescents With First Episode Major Depressive Disorder |
| title_sort | abnormalities in electroencephalographic microstates among adolescents with first episode major depressive disorder |
| topic | adolescents major depressive disorder EEG resting state EEG microstate first-episode depression |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.775156/full |
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