Exploring Genetic Interactions with Telomere Protection Gene <i>pot1</i> in Fission Yeast
The regulation of telomere length has a significant impact on cancer risk and aging in humans. Circular chromosomes are found in humans and are often unstable during mitosis, resulting in genome instability. Some types of cancer have a high frequency of a circular chromosome. Fission yeast is a good...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/2/370 |
| _version_ | 1797622054559678464 |
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| author | Masaru Ueno |
| author_facet | Masaru Ueno |
| author_sort | Masaru Ueno |
| collection | DOAJ |
| description | The regulation of telomere length has a significant impact on cancer risk and aging in humans. Circular chromosomes are found in humans and are often unstable during mitosis, resulting in genome instability. Some types of cancer have a high frequency of a circular chromosome. Fission yeast is a good model for studying the formation and stability of circular chromosomes as deletion of <i>pot1</i> (encoding a telomere protection protein) results in rapid telomere degradation and chromosome fusion. Pot1 binds to single-stranded telomere DNA and is conserved from fission yeast to humans. Loss of <i>pot1</i> leads to viable strains in which all three fission yeast chromosomes become circular. In this review, I will introduce <i>pot1</i> genetic interactions as these inform on processes such as the degradation of uncapped telomeres, chromosome fusion, and maintenance of circular chromosomes. Therefore, exploring genes that genetically interact with <i>pot1</i> contributes to finding new genes and/or new functions of genes related to the maintenance of telomeres and/or circular chromosomes. |
| first_indexed | 2024-03-11T09:05:50Z |
| format | Article |
| id | doaj.art-44c201fcb8b14a859b68566ff563b924 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T09:05:50Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-44c201fcb8b14a859b68566ff563b9242023-11-16T19:24:15ZengMDPI AGBiomolecules2218-273X2023-02-0113237010.3390/biom13020370Exploring Genetic Interactions with Telomere Protection Gene <i>pot1</i> in Fission YeastMasaru Ueno0Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8530, JapanThe regulation of telomere length has a significant impact on cancer risk and aging in humans. Circular chromosomes are found in humans and are often unstable during mitosis, resulting in genome instability. Some types of cancer have a high frequency of a circular chromosome. Fission yeast is a good model for studying the formation and stability of circular chromosomes as deletion of <i>pot1</i> (encoding a telomere protection protein) results in rapid telomere degradation and chromosome fusion. Pot1 binds to single-stranded telomere DNA and is conserved from fission yeast to humans. Loss of <i>pot1</i> leads to viable strains in which all three fission yeast chromosomes become circular. In this review, I will introduce <i>pot1</i> genetic interactions as these inform on processes such as the degradation of uncapped telomeres, chromosome fusion, and maintenance of circular chromosomes. Therefore, exploring genes that genetically interact with <i>pot1</i> contributes to finding new genes and/or new functions of genes related to the maintenance of telomeres and/or circular chromosomes.https://www.mdpi.com/2218-273X/13/2/370telomerering chromosomeDNA repairchromosome segregation |
| spellingShingle | Masaru Ueno Exploring Genetic Interactions with Telomere Protection Gene <i>pot1</i> in Fission Yeast Biomolecules telomere ring chromosome DNA repair chromosome segregation |
| title | Exploring Genetic Interactions with Telomere Protection Gene <i>pot1</i> in Fission Yeast |
| title_full | Exploring Genetic Interactions with Telomere Protection Gene <i>pot1</i> in Fission Yeast |
| title_fullStr | Exploring Genetic Interactions with Telomere Protection Gene <i>pot1</i> in Fission Yeast |
| title_full_unstemmed | Exploring Genetic Interactions with Telomere Protection Gene <i>pot1</i> in Fission Yeast |
| title_short | Exploring Genetic Interactions with Telomere Protection Gene <i>pot1</i> in Fission Yeast |
| title_sort | exploring genetic interactions with telomere protection gene i pot1 i in fission yeast |
| topic | telomere ring chromosome DNA repair chromosome segregation |
| url | https://www.mdpi.com/2218-273X/13/2/370 |
| work_keys_str_mv | AT masaruueno exploringgeneticinteractionswithtelomereprotectiongeneipot1iinfissionyeast |