Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationships
Background: Alu elements are attractive markers for population genetics, disease, forensics and paternity analyses, due to their particular characteristics. Five polymorphic Alu insertions within the MHC class I region have been little examined in human populations. Aim: The analysis of the genetic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-02-01
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| Series: | Annals of Human Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/03014460.2019.1620854 |
| _version_ | 1797685561631178752 |
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| author | Said Nassor Abeid Majida Motrane Hamid Farhane Nourdin Harich |
| author_facet | Said Nassor Abeid Majida Motrane Hamid Farhane Nourdin Harich |
| author_sort | Said Nassor Abeid |
| collection | DOAJ |
| description | Background: Alu elements are attractive markers for population genetics, disease, forensics and paternity analyses, due to their particular characteristics. Five polymorphic Alu insertions within the MHC class I region have been little examined in human populations. Aim: The analysis of the genetic diversity of autochthonous Comorians from the three major islands of the archipelago by these polymorphic MHC Alus and to assess their relationships together and with other populations. Subjects and methods: Two hundred and fifty-seven unrelated participants from the Comoros archipelago, Grande Comore (86), Anjouan (93) and Moheli (78), were examined for five MHC Alu insertions. The data were analysed for intra- and inter-population genetic variation. Results: All MHC Alu were polymorphic in the three samples and only one significant differentiation was observed between Anjouan and Moheli. According to the MDS and AMOVA results, the populations included in the inter-population analyses were grouped in three major clusters according to their genetic ancestry. The haplotype diversity showed by the Comorians is higher than in previously studied African populations and occupies an intermediate position between African and Asian clusters. Conclusion: MHC Alu insertions are useful markers to study micro-geographical genetic variations. Using these polymorphisms, new insights have been obtained about the biological history and evolution of the Comoros. |
| first_indexed | 2024-03-12T00:46:55Z |
| format | Article |
| id | doaj.art-44c312adf3844d0bb4b9bcaa8dd17442 |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-12T00:46:55Z |
| publishDate | 2019-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-44c312adf3844d0bb4b9bcaa8dd174422023-09-14T15:36:10ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332019-02-0146216917410.1080/03014460.2019.16208541620854Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationshipsSaid Nassor Abeid0Majida Motrane1Hamid Farhane2Nourdin Harich3Faculté des Sciences, Université Chouaïb DoukkaliFaculté des Sciences, Université Chouaïb DoukkaliFaculté des Sciences, Université Chouaïb DoukkaliFaculté des Sciences, Université Chouaïb DoukkaliBackground: Alu elements are attractive markers for population genetics, disease, forensics and paternity analyses, due to their particular characteristics. Five polymorphic Alu insertions within the MHC class I region have been little examined in human populations. Aim: The analysis of the genetic diversity of autochthonous Comorians from the three major islands of the archipelago by these polymorphic MHC Alus and to assess their relationships together and with other populations. Subjects and methods: Two hundred and fifty-seven unrelated participants from the Comoros archipelago, Grande Comore (86), Anjouan (93) and Moheli (78), were examined for five MHC Alu insertions. The data were analysed for intra- and inter-population genetic variation. Results: All MHC Alu were polymorphic in the three samples and only one significant differentiation was observed between Anjouan and Moheli. According to the MDS and AMOVA results, the populations included in the inter-population analyses were grouped in three major clusters according to their genetic ancestry. The haplotype diversity showed by the Comorians is higher than in previously studied African populations and occupies an intermediate position between African and Asian clusters. Conclusion: MHC Alu insertions are useful markers to study micro-geographical genetic variations. Using these polymorphisms, new insights have been obtained about the biological history and evolution of the Comoros.http://dx.doi.org/10.1080/03014460.2019.1620854alu polymorphismsmhccomorosafrica |
| spellingShingle | Said Nassor Abeid Majida Motrane Hamid Farhane Nourdin Harich Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationships Annals of Human Biology alu polymorphisms mhc comoros africa |
| title | Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationships |
| title_full | Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationships |
| title_fullStr | Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationships |
| title_full_unstemmed | Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationships |
| title_short | Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationships |
| title_sort | alu elements within the human major histocompatibility class i region in the comoros islands genetic variation and population relationships |
| topic | alu polymorphisms mhc comoros africa |
| url | http://dx.doi.org/10.1080/03014460.2019.1620854 |
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