Increased activity of enzymes involved in purine metabolism as one of the factors of rectal cancer pathogenesis
Aim: to study changes in the activities of purine nucleotide degradation enzymes – adenosine deaminase (ADA) and xanthine oxidase (XO) in patients with rectum cancer (RC).Material and Methods. The activity of purine nucleotide degradation enzymes was studied in blood plasma and tissue homogenates: t...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2023-02-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/2435 |
| _version_ | 1797875714994733056 |
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| author | S. A. Zuikov G. E. Polunin |
| author_facet | S. A. Zuikov G. E. Polunin |
| author_sort | S. A. Zuikov |
| collection | DOAJ |
| description | Aim: to study changes in the activities of purine nucleotide degradation enzymes – adenosine deaminase (ADA) and xanthine oxidase (XO) in patients with rectum cancer (RC).Material and Methods. The activity of purine nucleotide degradation enzymes was studied in blood plasma and tissue homogenates: tumor tissue and normal rectal mucosa in 70 patients with stage I–IV RC. The histological type of RC was adenocarcinoma. The levels of ADA and XO activities were measured using spectrophotometry.Results. The activity of ADA and XO in blood serum of RC patients was significantly higher than that of healthy people. A significant increase in the activity of ADA and XO in tumor tissue compared to normal tissue was also found. The relationship between the activities of the enzymes of purine catabolism in blood plasma and tissues were revealed. An increase in purine catabolism depending on the stage of RC was found.Conclusion. The increased ADA and XO activities indicated the enhanced purine catabolism not only in malignant transformation, but also in tumor progression. |
| first_indexed | 2024-04-10T01:51:59Z |
| format | Article |
| id | doaj.art-44c63e40d1d549b0903e6f903ff98ee2 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:51:59Z |
| publishDate | 2023-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-44c63e40d1d549b0903e6f903ff98ee22023-03-13T09:05:56ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682023-02-012219510010.21294/1814-4861-2023-22-1-95-1001089Increased activity of enzymes involved in purine metabolism as one of the factors of rectal cancer pathogenesisS. A. Zuikov0G. E. Polunin1ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»Aim: to study changes in the activities of purine nucleotide degradation enzymes – adenosine deaminase (ADA) and xanthine oxidase (XO) in patients with rectum cancer (RC).Material and Methods. The activity of purine nucleotide degradation enzymes was studied in blood plasma and tissue homogenates: tumor tissue and normal rectal mucosa in 70 patients with stage I–IV RC. The histological type of RC was adenocarcinoma. The levels of ADA and XO activities were measured using spectrophotometry.Results. The activity of ADA and XO in blood serum of RC patients was significantly higher than that of healthy people. A significant increase in the activity of ADA and XO in tumor tissue compared to normal tissue was also found. The relationship between the activities of the enzymes of purine catabolism in blood plasma and tissues were revealed. An increase in purine catabolism depending on the stage of RC was found.Conclusion. The increased ADA and XO activities indicated the enhanced purine catabolism not only in malignant transformation, but also in tumor progression.https://www.siboncoj.ru/jour/article/view/2435аденозиндезаминазаксантиноксидазапуриновый обменрак прямой кишкиплазма кровигомогенат тканей |
| spellingShingle | S. A. Zuikov G. E. Polunin Increased activity of enzymes involved in purine metabolism as one of the factors of rectal cancer pathogenesis Сибирский онкологический журнал аденозиндезаминаза ксантиноксидаза пуриновый обмен рак прямой кишки плазма крови гомогенат тканей |
| title | Increased activity of enzymes involved in purine metabolism as one of the factors of rectal cancer pathogenesis |
| title_full | Increased activity of enzymes involved in purine metabolism as one of the factors of rectal cancer pathogenesis |
| title_fullStr | Increased activity of enzymes involved in purine metabolism as one of the factors of rectal cancer pathogenesis |
| title_full_unstemmed | Increased activity of enzymes involved in purine metabolism as one of the factors of rectal cancer pathogenesis |
| title_short | Increased activity of enzymes involved in purine metabolism as one of the factors of rectal cancer pathogenesis |
| title_sort | increased activity of enzymes involved in purine metabolism as one of the factors of rectal cancer pathogenesis |
| topic | аденозиндезаминаза ксантиноксидаза пуриновый обмен рак прямой кишки плазма крови гомогенат тканей |
| url | https://www.siboncoj.ru/jour/article/view/2435 |
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