Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway

Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway

<p>Abstract</p> <p>Background</p> <p>Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor cell migration,...

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Bibliographic Details
Main Authors: Isozaki Misako, Itoh Tatsuki, Satou Takao, Ogaki Mitsuhiko, Nakamura Haruyuki, Shoji Kaori, Yamazoe Yuzuru, Tsubaki Masanobu, Kidera Yasuhiro, Kaneko Junichi, Tanimori Yoshihiro, Yanae Masashi, Nishida Shozo
Format: Article
Language:English
Published: BMC 2010-09-01
Series:Journal of Experimental & Clinical Cancer Research
Online Access:http://www.jeccr.com/content/29/1/127

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http://www.jeccr.com/content/29/1/127

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