Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer
Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we synthesized stealth liposomes encapsulating hydro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/12/2073 |
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| author | Nahid S. Awad Mohamed Haider Vinod Paul Nour M. AlSawaftah Jayalakshmi Jagal Renu Pasricha Ghaleb A. Husseini |
| author_facet | Nahid S. Awad Mohamed Haider Vinod Paul Nour M. AlSawaftah Jayalakshmi Jagal Renu Pasricha Ghaleb A. Husseini |
| author_sort | Nahid S. Awad |
| collection | DOAJ |
| description | Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we synthesized stealth liposomes encapsulating hydrophilic graphene quantum dots and triggered their release with ultrasound with the goal of developing a safer and well-controlled modality to deliver fluorescent markers to tumors. Our results confirmed the successful encapsulation of the QDs inside the core of the liposomes and showed no effect on the size or stability of the prepared liposomes. Our results also showed that low-frequency ultrasound is an effective method to release QDs encapsulated inside the liposomes in a spatially and temporally controlled manner to ensure the effective delivery of QDs to tumors while reducing their systemic toxicity. |
| first_indexed | 2024-03-10T03:19:17Z |
| format | Article |
| id | doaj.art-44cd51b2a66b4a55b15360551af93184 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:19:17Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-44cd51b2a66b4a55b15360551af931842023-11-23T10:05:32ZengMDPI AGPharmaceutics1999-49232021-12-011312207310.3390/pharmaceutics13122073Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal CancerNahid S. Awad0Mohamed Haider1Vinod Paul2Nour M. AlSawaftah3Jayalakshmi Jagal4Renu Pasricha5Ghaleb A. Husseini6Department of Chemical Engineering, Collage of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab EmiratesDepartment of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah P.O. Box 27272, United Arab EmiratesDepartment of Chemical Engineering, Collage of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab EmiratesDepartment of Chemical Engineering, Collage of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab EmiratesResearch Institute for Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab EmiratesCore Technology Platforms Operations, New York University Abu Dhabi, Abu Dhabi P.O. Box 129188, United Arab EmiratesDepartment of Chemical Engineering, Collage of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab EmiratesQuantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we synthesized stealth liposomes encapsulating hydrophilic graphene quantum dots and triggered their release with ultrasound with the goal of developing a safer and well-controlled modality to deliver fluorescent markers to tumors. Our results confirmed the successful encapsulation of the QDs inside the core of the liposomes and showed no effect on the size or stability of the prepared liposomes. Our results also showed that low-frequency ultrasound is an effective method to release QDs encapsulated inside the liposomes in a spatially and temporally controlled manner to ensure the effective delivery of QDs to tumors while reducing their systemic toxicity.https://www.mdpi.com/1999-4923/13/12/2073quantum dotsliposomeslow-frequency ultrasoundcontrolled release |
| spellingShingle | Nahid S. Awad Mohamed Haider Vinod Paul Nour M. AlSawaftah Jayalakshmi Jagal Renu Pasricha Ghaleb A. Husseini Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer Pharmaceutics quantum dots liposomes low-frequency ultrasound controlled release |
| title | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_full | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_fullStr | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_full_unstemmed | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_short | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_sort | ultrasound triggered liposomes encapsulating quantum dots as safe fluorescent markers for colorectal cancer |
| topic | quantum dots liposomes low-frequency ultrasound controlled release |
| url | https://www.mdpi.com/1999-4923/13/12/2073 |
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