Dosage Strategy of Linezolid According to the Trough Concentration Target and Renal Function in Chinese Critically Ill Patients

Dosage Strategy of Linezolid According to the Trough Concentration Target and Renal Function in Chinese Critically Ill Patients

Background: Linezolid is associated with myelosuppression, which may cause failure in optimally treating bacterial infections. The study aimed to define the pharmacokinetic/toxicodynamic (PK/TD) threshold for critically ill patients and to identify a dosing strategy for critically ill patients with...

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Bibliographic Details
Main Authors: Fan Wu, Xiao-Shan Zhang, Ying Dai, Zi-Ye Zhou, Chun-Hong Zhang, Lu Han, Fang-Min Xu, Ye-Xuan Wang, Da-Wei Shi, Guan-Yang Lin, Xu-Ben Yu, Fang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
linezolid
population pharmacokinetics
myelosuppression
dosage strategy
renal function
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.844567/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.844567/full

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