3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis
Abstract Electrospinning is an effective method to fabricate fibrous scaffolds that mimic the ECM of bone tissue on a nano- to macro-scale. However, a limitation of electrospun fibrous scaffolds for bone tissue engineering is the structure formed by densely compacted fibers, which significantly impe...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-58135-2 |
| _version_ | 1797233585902583808 |
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| author | Sun Hee Cho Soonchul Lee Jeong In Kim |
| author_facet | Sun Hee Cho Soonchul Lee Jeong In Kim |
| author_sort | Sun Hee Cho |
| collection | DOAJ |
| description | Abstract Electrospinning is an effective method to fabricate fibrous scaffolds that mimic the ECM of bone tissue on a nano- to macro-scale. However, a limitation of electrospun fibrous scaffolds for bone tissue engineering is the structure formed by densely compacted fibers, which significantly impedes cell infiltration and tissue ingrowth. To address this problem, several researchers have developed numerous techniques for fabricating 3D fibrous scaffolds with customized topography and pore size. Despite the success in developing various 3D electrospun scaffolds based on fiber repulsion, the lack of contact points between fibers in those scaffolds has been shown to hinder cell attachment, migration, proliferation, and differentiation due to excessive movement of the fibers. In this article, we introduce a Dianthus caryophyllus-inspired scaffold fabricated using SIAC-PE, a modified collector under specific viscosity conditions of PCL/LA solution. The developed scaffold mimicking the structural similarities of the nature-inspired design presented enhanced cell proliferation, infiltration, and increased expression of bone-related factors by reducing fiber movements, presenting high space interconnection, high porosity, and controlled fiber topography. |
| first_indexed | 2024-04-24T16:18:31Z |
| format | Article |
| id | doaj.art-44d1dd96f12c409a9a12674e4e147639 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T16:18:31Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-44d1dd96f12c409a9a12674e4e1476392024-03-31T11:20:03ZengNature PortfolioScientific Reports2045-23222024-03-0114111210.1038/s41598-024-58135-23D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesisSun Hee Cho0Soonchul Lee1Jeong In Kim2Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National UniversityDepartment of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of MedicineDepartment of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of MedicineAbstract Electrospinning is an effective method to fabricate fibrous scaffolds that mimic the ECM of bone tissue on a nano- to macro-scale. However, a limitation of electrospun fibrous scaffolds for bone tissue engineering is the structure formed by densely compacted fibers, which significantly impedes cell infiltration and tissue ingrowth. To address this problem, several researchers have developed numerous techniques for fabricating 3D fibrous scaffolds with customized topography and pore size. Despite the success in developing various 3D electrospun scaffolds based on fiber repulsion, the lack of contact points between fibers in those scaffolds has been shown to hinder cell attachment, migration, proliferation, and differentiation due to excessive movement of the fibers. In this article, we introduce a Dianthus caryophyllus-inspired scaffold fabricated using SIAC-PE, a modified collector under specific viscosity conditions of PCL/LA solution. The developed scaffold mimicking the structural similarities of the nature-inspired design presented enhanced cell proliferation, infiltration, and increased expression of bone-related factors by reducing fiber movements, presenting high space interconnection, high porosity, and controlled fiber topography.https://doi.org/10.1038/s41598-024-58135-2Electrospinning3D fibersCottony fibersBiomimetic scaffoldsOsteogenesisBone tissue engineering |
| spellingShingle | Sun Hee Cho Soonchul Lee Jeong In Kim 3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis Scientific Reports Electrospinning 3D fibers Cottony fibers Biomimetic scaffolds Osteogenesis Bone tissue engineering |
| title | 3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis |
| title_full | 3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis |
| title_fullStr | 3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis |
| title_full_unstemmed | 3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis |
| title_short | 3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis |
| title_sort | 3d cotton type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis |
| topic | Electrospinning 3D fibers Cottony fibers Biomimetic scaffolds Osteogenesis Bone tissue engineering |
| url | https://doi.org/10.1038/s41598-024-58135-2 |
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