Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian Women
PURPOSECervical cancer screening is one of the strategies to prevent the disease among women at risk. Human papillomavirus (HPV) DNA testing is increasingly used as the cervical cancer screening method because of its high sensitivity. Self-collection of cervical specimens has the potential to improv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2021-12-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO.20.00598 |
| _version_ | 1818314476395429888 |
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| author | Johnson J. Katanga Vibeke Rasch Rachel Manongi Andrea B. Pembe Julius D. Mwaiselage Susanne K. Kjaer |
| author_facet | Johnson J. Katanga Vibeke Rasch Rachel Manongi Andrea B. Pembe Julius D. Mwaiselage Susanne K. Kjaer |
| author_sort | Johnson J. Katanga |
| collection | DOAJ |
| description | PURPOSECervical cancer screening is one of the strategies to prevent the disease among women at risk. Human papillomavirus (HPV) DNA testing is increasingly used as the cervical cancer screening method because of its high sensitivity. Self-collection of cervical specimens has the potential to improve participation. However, there is only limited information on comparison between self-collected and provider-collected samples with regard to detection of high-risk HPV using the careHPV method. The study aimed to compare HPV detection by careHPV in self-collected and provider-collected cervical samples and to assess the acceptability of self-collection techniques.MATERIAL AND METHODSWomen attending cervical cancer screening clinics at Ocean Road Cancer Institute, Kilimanjaro Christian Medical Centre or Mawenzi Hospital in Tanzania were included in the study. They underwent a face-to-face interview, HIV testing, and collected a self-sample using Evalyn Brush. Subsequently, they had a cervical sample taken by a health provider. Both samples were tested for high-risk HPV DNA using careHPV.RESULTSOverall, 464 women participated in the study. The high-risk HPV prevalence was 19.0% (95% CI, 15.6 to 22.9) in the health provider samples, but lower (13.8%; 95% CI, 10.9 to 17.3) in the self-collected samples. There was a good overall agreement 90.5% (95% CI, 87.5 to 93.0) and concordance (κ = 0.66; 95% CI, 0.56 to 0.75) between the two sets of samples. Sensitivity and specificity were 61.4% (95% CI, 50.4 to 71.6) and 97.3% (95% CI, 95.2 to 98.7), respectively, varying with age. Most women preferred self-collection (79.8%).CONCLUSIONOverall, self-sampling seems to be a reliable alternative to health-provider collection and is acceptable to the majority of women. However, instructions on proper procedures for sample collection to the women are important. |
| first_indexed | 2024-12-13T08:50:15Z |
| format | Article |
| id | doaj.art-44d60bb52d95468b9f1a61357d7a6593 |
| institution | Directory Open Access Journal |
| issn | 2687-8941 |
| language | English |
| last_indexed | 2024-12-13T08:50:15Z |
| publishDate | 2021-12-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj.art-44d60bb52d95468b9f1a61357d7a65932022-12-21T23:53:23ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412021-12-01798599110.1200/GO.20.00598Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian WomenJohnson J. Katanga0Vibeke Rasch1Rachel Manongi2Andrea B. Pembe3Julius D. Mwaiselage4Susanne K. Kjaer5Ocean Road Cancer Institute, Dar es Salaam, TanzaniaDepartment of Gynaecology and Obstetrics, Odense University Hospital, Odense, DenmarkInstitute of Public Health, Kilimanjaro Christian Medical University College, Kilimanjaro, TanzaniaMuhimbili University of Health and Allied Sciences, Dar es Salaam, TanzaniaOcean Road Cancer Institute, Dar es Salaam, TanzaniaDanish Cancer Society Research Center, Unit of Virus, Lifestyle and Genes, Copenhagen, DenmarkPURPOSECervical cancer screening is one of the strategies to prevent the disease among women at risk. Human papillomavirus (HPV) DNA testing is increasingly used as the cervical cancer screening method because of its high sensitivity. Self-collection of cervical specimens has the potential to improve participation. However, there is only limited information on comparison between self-collected and provider-collected samples with regard to detection of high-risk HPV using the careHPV method. The study aimed to compare HPV detection by careHPV in self-collected and provider-collected cervical samples and to assess the acceptability of self-collection techniques.MATERIAL AND METHODSWomen attending cervical cancer screening clinics at Ocean Road Cancer Institute, Kilimanjaro Christian Medical Centre or Mawenzi Hospital in Tanzania were included in the study. They underwent a face-to-face interview, HIV testing, and collected a self-sample using Evalyn Brush. Subsequently, they had a cervical sample taken by a health provider. Both samples were tested for high-risk HPV DNA using careHPV.RESULTSOverall, 464 women participated in the study. The high-risk HPV prevalence was 19.0% (95% CI, 15.6 to 22.9) in the health provider samples, but lower (13.8%; 95% CI, 10.9 to 17.3) in the self-collected samples. There was a good overall agreement 90.5% (95% CI, 87.5 to 93.0) and concordance (κ = 0.66; 95% CI, 0.56 to 0.75) between the two sets of samples. Sensitivity and specificity were 61.4% (95% CI, 50.4 to 71.6) and 97.3% (95% CI, 95.2 to 98.7), respectively, varying with age. Most women preferred self-collection (79.8%).CONCLUSIONOverall, self-sampling seems to be a reliable alternative to health-provider collection and is acceptable to the majority of women. However, instructions on proper procedures for sample collection to the women are important.https://ascopubs.org/doi/10.1200/GO.20.00598 |
| spellingShingle | Johnson J. Katanga Vibeke Rasch Rachel Manongi Andrea B. Pembe Julius D. Mwaiselage Susanne K. Kjaer Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian Women JCO Global Oncology |
| title | Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian Women |
| title_full | Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian Women |
| title_fullStr | Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian Women |
| title_full_unstemmed | Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian Women |
| title_short | Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian Women |
| title_sort | concordance in hpv detection between self collected and health provider collected cervicovaginal samples using carehpv in tanzanian women |
| url | https://ascopubs.org/doi/10.1200/GO.20.00598 |
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