Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers
In this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of ch...
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| Format: | Article |
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2021-03-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/7/1007 |
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| author | Valeriya V. Kardumyan Nadejda A. Aksenova Victoria A. Timofeeva Alexey V. Krivandin Olga V. Shatalova Alexander S. Dubovik Irina G. Plashchina Peter S. Timashev Anna B. Solovieva |
| author_facet | Valeriya V. Kardumyan Nadejda A. Aksenova Victoria A. Timofeeva Alexey V. Krivandin Olga V. Shatalova Alexander S. Dubovik Irina G. Plashchina Peter S. Timashev Anna B. Solovieva |
| author_sort | Valeriya V. Kardumyan |
| collection | DOAJ |
| description | In this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of chitosan (CT). Water-soluble compounds (dimegin and trisodium salt of chlorin e6 (Ce6)) and hydrophobic porphyrins (tetraphenylporphyrin (TPP) and its fluorine derivative (TPPF20)) were used as PSs. It was shown that the use of chitosan (Mw ~100 kDa) makes it possible to obtain a system whose activity is comparable to that of the photosensitizer-amphiphilic polymer systems. Thus, the previously observed drop in the photosensitizing activity of PS in the presence of a polysaccharide and amphiphilic polymers (AP) was absent in this case. At the same time, chitosan had practically no inhibitory effect on hydrophobic porphyrins solubilized by Pluronic F127. |
| first_indexed | 2024-03-10T12:55:58Z |
| format | Article |
| id | doaj.art-44d6433bb94640cc9d4987d2abee1b1b |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T12:55:58Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-44d6433bb94640cc9d4987d2abee1b1b2023-11-21T11:55:19ZengMDPI AGPolymers2073-43602021-03-01137100710.3390/polym13071007Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic PolymersValeriya V. Kardumyan0Nadejda A. Aksenova1Victoria A. Timofeeva2Alexey V. Krivandin3Olga V. Shatalova4Alexander S. Dubovik5Irina G. Plashchina6Peter S. Timashev7Anna B. Solovieva8N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119991, RussiaN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119991, RussiaN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119991, RussiaN.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119334, RussiaN.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119334, RussiaN.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119334, RussiaN.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119334, RussiaN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119991, RussiaN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119991, RussiaIn this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of chitosan (CT). Water-soluble compounds (dimegin and trisodium salt of chlorin e6 (Ce6)) and hydrophobic porphyrins (tetraphenylporphyrin (TPP) and its fluorine derivative (TPPF20)) were used as PSs. It was shown that the use of chitosan (Mw ~100 kDa) makes it possible to obtain a system whose activity is comparable to that of the photosensitizer-amphiphilic polymer systems. Thus, the previously observed drop in the photosensitizing activity of PS in the presence of a polysaccharide and amphiphilic polymers (AP) was absent in this case. At the same time, chitosan had practically no inhibitory effect on hydrophobic porphyrins solubilized by Pluronic F127.https://www.mdpi.com/2073-4360/13/7/1007chitosanporphyrinPluronic F127polyvinylpyrrolidonetryptophan photo-oxidation |
| spellingShingle | Valeriya V. Kardumyan Nadejda A. Aksenova Victoria A. Timofeeva Alexey V. Krivandin Olga V. Shatalova Alexander S. Dubovik Irina G. Plashchina Peter S. Timashev Anna B. Solovieva Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers Polymers chitosan porphyrin Pluronic F127 polyvinylpyrrolidone tryptophan photo-oxidation |
| title | Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers |
| title_full | Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers |
| title_fullStr | Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers |
| title_full_unstemmed | Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers |
| title_short | Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers |
| title_sort | effect of chitosan on the activity of water soluble and hydrophobic porphyrin photosensitizers solubilized by amphiphilic polymers |
| topic | chitosan porphyrin Pluronic F127 polyvinylpyrrolidone tryptophan photo-oxidation |
| url | https://www.mdpi.com/2073-4360/13/7/1007 |
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