Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern
Abstract Background Nosocomial infections (NIs) could lead to considerably higher mortality rates, length of the hospital stays and costs, and represent a serious public health concern worldwide. Besides, the unreasonable use of antibiotics could lead to get resistant to different antibiotics and cr...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12941-022-00496-5 |
| _version_ | 1818280227666657280 |
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| author | Mehrnoush Afsharipour Shima Mahmoudi Hojatollahh Raji Babak Pourakbari Setareh Mamishi |
| author_facet | Mehrnoush Afsharipour Shima Mahmoudi Hojatollahh Raji Babak Pourakbari Setareh Mamishi |
| author_sort | Mehrnoush Afsharipour |
| collection | DOAJ |
| description | Abstract Background Nosocomial infections (NIs) could lead to considerably higher mortality rates, length of the hospital stays and costs, and represent a serious public health concern worldwide. Besides, the unreasonable use of antibiotics could lead to get resistant to different antibiotics and create limited therapeutic options, increased risks of treatment failure and poor patient management. The current study aimed to evaluate the prevalence and antimicrobial susceptibility of NIs in an Iranian referral pediatrics hospital during 3 years. Methods During the 3-year period, all electronic medical records of nosocomial infection episodes in hospitalized patients were retrospectively reviewed. The bacterial and fungal profile and antimicrobial susceptibility profiles of isolates recovered from different samples of patients with NIs were determined. Results In this study, a total of 718 patients with NIs was found, among which 61.3% were male (N = 440). The median age of the patients was 2.5 years (IQR: 1 month to 3 years). Klebsiella pneumonia and Candida spp. isolates were the most prevalent microorganisms (N = 125, 17.4%, N = 121, 16.9%, respectively), followed by Pseudomonas aeruginosa (N = 72, 10%) and Coagulase-negative Staphylococci (CoNS) (N = 69, 9.6%). Pseudomonas aeroginusa strains showed high sensitivity to the studied antibiotics. Acinetobacter baumannii strains displayed more than 90% resistance to the almost all antibiotics. All of the tested isolates of S. maltophilia were susceptible to Trimethoprim−sulfamethoxazole (100%) and showed high susceptibility rate to ciprofloxacin (96.4%). Vancomycin resistance was not reported in S. aureus isolates, while 64% of Enterococcus spp. was resistant to vancomycin. The rates of methicillin resistance for S. aureus and CoNS isolates were 45.5% and 85.7%, respectively. Conclusions High frequency of antimicrobial resistance to the commonly tested antibiotics is a concerning alarm. Therefore, effective infection control programs and rational antibiotic use policies should be established promptly. |
| first_indexed | 2024-12-12T23:45:53Z |
| format | Article |
| id | doaj.art-44d681f16c7146c0acd21197ca6041d4 |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-12-12T23:45:53Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-44d681f16c7146c0acd21197ca6041d42022-12-22T00:06:51ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112022-02-012111710.1186/s12941-022-00496-5Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance patternMehrnoush Afsharipour0Shima Mahmoudi1Hojatollahh Raji2Babak Pourakbari3Setareh Mamishi4Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical SciencesPediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical SciencesDepartment of Pediatric Surgery, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical SciencesPediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical SciencesPediatric Infectious Disease Research Center, Tehran University of Medical SciencesAbstract Background Nosocomial infections (NIs) could lead to considerably higher mortality rates, length of the hospital stays and costs, and represent a serious public health concern worldwide. Besides, the unreasonable use of antibiotics could lead to get resistant to different antibiotics and create limited therapeutic options, increased risks of treatment failure and poor patient management. The current study aimed to evaluate the prevalence and antimicrobial susceptibility of NIs in an Iranian referral pediatrics hospital during 3 years. Methods During the 3-year period, all electronic medical records of nosocomial infection episodes in hospitalized patients were retrospectively reviewed. The bacterial and fungal profile and antimicrobial susceptibility profiles of isolates recovered from different samples of patients with NIs were determined. Results In this study, a total of 718 patients with NIs was found, among which 61.3% were male (N = 440). The median age of the patients was 2.5 years (IQR: 1 month to 3 years). Klebsiella pneumonia and Candida spp. isolates were the most prevalent microorganisms (N = 125, 17.4%, N = 121, 16.9%, respectively), followed by Pseudomonas aeruginosa (N = 72, 10%) and Coagulase-negative Staphylococci (CoNS) (N = 69, 9.6%). Pseudomonas aeroginusa strains showed high sensitivity to the studied antibiotics. Acinetobacter baumannii strains displayed more than 90% resistance to the almost all antibiotics. All of the tested isolates of S. maltophilia were susceptible to Trimethoprim−sulfamethoxazole (100%) and showed high susceptibility rate to ciprofloxacin (96.4%). Vancomycin resistance was not reported in S. aureus isolates, while 64% of Enterococcus spp. was resistant to vancomycin. The rates of methicillin resistance for S. aureus and CoNS isolates were 45.5% and 85.7%, respectively. Conclusions High frequency of antimicrobial resistance to the commonly tested antibiotics is a concerning alarm. Therefore, effective infection control programs and rational antibiotic use policies should be established promptly.https://doi.org/10.1186/s12941-022-00496-5Nosocomial infectionsAntimicrobial susceptibilityPediatrics |
| spellingShingle | Mehrnoush Afsharipour Shima Mahmoudi Hojatollahh Raji Babak Pourakbari Setareh Mamishi Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern Annals of Clinical Microbiology and Antimicrobials Nosocomial infections Antimicrobial susceptibility Pediatrics |
| title | Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern |
| title_full | Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern |
| title_fullStr | Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern |
| title_full_unstemmed | Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern |
| title_short | Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern |
| title_sort | three year evaluation of the nosocomial infections in pediatrics bacterial and fungal profile and antimicrobial resistance pattern |
| topic | Nosocomial infections Antimicrobial susceptibility Pediatrics |
| url | https://doi.org/10.1186/s12941-022-00496-5 |
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