Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation

Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation

Microtubules (MTs), dynamic polymers of α/β-tubulin heterodimers found in all eukaryotes, are involved in cytoplasm spatial organization, intracellular transport, cell polarity, migration and division, and in cilia biology. MTs functional diversity depends on the differential expression of distinct...

Full description

Bibliographic Details
Main Authors:	Bruno Carmona, H. Susana Marinho, Catarina Lopes Matos, Sofia Nolasco, Helena Soares
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Series:	Biology
Subjects:	acetylation tubulin Lys40 microtubules post-translational modifications αTAT1
Online Access:	https://www.mdpi.com/2079-7737/12/4/561

Similar Items

The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and Cancer
by: Daniela Trisciuoglio, et al.
Published: (2021-12-01)

Tubulin Post-translational Modifications: Potential Therapeutic Approaches to Heart Failure
by: Chang Liu, et al.
Published: (2022-04-01)

Marginal band microtubules are acetylated by αTAT1
by: Anne-Sophie Ribba, et al.
Published: (2021-05-01)

The Altered Hepatic Tubulin Code in Alcoholic Liver Disease
by: Jennifer L. Groebner, et al.
Published: (2015-09-01)

Deciphering the Tubulin Language: Molecular Determinants and Readout Mechanisms of the Tubulin Code in Neurons
by: Riccardo Zocchi, et al.
Published: (2023-02-01)

Acetylated alpha-tubulin in Trypanosoma cruzi: immunocytochemical localization
by: Thais Souto-Padron, et al.
Published: (1993-12-01)

Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease
by: José Martínez-Hernández, et al.
Published: (2022-08-01)

The Tubulin Code in Mitosis and Cancer
by: Danilo Lopes, et al.
Published: (2020-10-01)

Balancing Act: Tubulin Glutamylation and Microtubule Dynamics in <i>Toxoplasma gondii</i>
by: Inês L. S. Delgado, et al.
Published: (2024-02-01)

Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation
by: Jessica Eira, et al.
Published: (2021-11-01)

A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation
by: David Siegel, et al.
Published: (2021-02-01)

Acetylated tubulin is essential for touch sensation in mice
by: Shane J Morley, et al.
Published: (2016-12-01)

Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation
by: Juliette van Dijk, et al.
Published: (2018-10-01)

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
by: Ivana Gasic, et al.
Published: (2020-04-01)

Expression of acetylated tubulin in the postnatal developing mouse cochlea
by: Wenjing Liu, et al.
Published: (2018-08-01)

Microtubule acetylation dyshomeostasis in Parkinson’s disease
by: Padmashri Naren, et al.
Published: (2023-05-01)

Microtubules in Microorganisms: How Tubulin Isotypes Contribute to Diverse Cytoskeletal Functions
by: Abesh Bera, et al.
Published: (2022-07-01)

The Amazing Evolutionary Complexity of Eukaryotic Tubulins: Lessons from Naegleria and the Multi-tubulin Hypothesis
by: Chandler Fulton
Published: (2022-04-01)

Tubulin and Tubulin Posttranslational Modifications in Alzheimer’s Disease and Vascular Dementia
by: Estibaliz Santiago-Mujika, et al.
Published: (2021-10-01)

Reconstituting Microtubules: A Decades-Long Effort From Building Block Identification to the Generation of Recombinant α/β-Tubulin
by: Shih-Chieh Ti
Published: (2022-04-01)

Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells
by: Filip Borys, et al.
Published: (2020-08-01)

Tubulin/microtubules as novel clozapine targets
by: Mizuki Hino, et al.
Published: (2022-03-01)

The Major Capsid Protein, VP1, of the Mouse Polyomavirus Stimulates the Activity of Tubulin Acetyltransferase 1 by Microtubule Stabilization
by: Lenka Horníková, et al.
Published: (2020-02-01)

Divalent cation hinder the solubilization of a tubulin kinase activity from Trypanosoma cruzi epimastigotes
by: GRACIELA UZCANGA, et al.
Published: (2003-01-01)

Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells
by: María Ovejero-Sánchez, et al.
Published: (2022-10-01)

Microtubules and their role in cellular stress in cancer
by: Joshua eMccarroll, et al.
Published: (2014-06-01)

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands
by: Francisco de Asís Balaguer, et al.
Published: (2019-03-01)

Reconstitution of the recombinant human γ-tubulin ring complex
by: Martin Würtz, et al.
Published: (2021-02-01)

The Expression and Function of Tubulin Isotypes in Caenorhabditis elegans
by: Yu-Ming Lu, et al.
Published: (2022-03-01)

A Tale of 12 Tails: Katanin Severing Activity Affected by Carboxy-Terminal Tail Sequences
by: K. Alice Lindsay, et al.
Published: (2023-03-01)

The microtubule cytoskeleton: An old validated target for novel therapeutic drugs
by: Laurence Lafanechère
Published: (2022-09-01)

Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation
by: Marie Octave, et al.
Published: (2021-12-01)

Isothiocyanates as Tubulin Polymerization Inhibitors—Synthesis and Structure–Activity Relationship Studies
by: Renata Grzywa, et al.
Published: (2023-09-01)

Regulation of Tubulin Gene Expression: From Isotype Identity to Functional Specialization
by: Ivana Gasic
Published: (2022-05-01)

Tubulin C-terminal post-translational modifications do not occur in wood forming tissue of Populus
by: Hao Hu, et al.
Published: (2016-10-01)

Colchicine Blocks Tubulin Heterodimer Recycling by Tubulin Cofactors TBCA, TBCB, and TBCE
by: Sofia Nolasco, et al.
Published: (2021-04-01)

Acetylation in Mitochondria Dynamics and Neurodegeneration
by: Jaylyn Waddell, et al.
Published: (2021-11-01)

Matrix stiffness‐induced α‐tubulin acetylation is required for skin fibrosis formation through activation of Yes‐associated protein
by: Dongsheng Wen, et al.
Published: (2023-08-01)

A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics
by: Elisabeth A Geyer, et al.
Published: (2015-10-01)

The Role of Runx2 in Microtubule Acetylation in Bone Metastatic Breast Cancer Cells
by: Ahmad Othman, et al.
Published: (2022-07-01)