RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks
Avian influenza is a disease with every possibility to evolve as a human-to-human pandemic arising out of frequent mutations and genetic reassortment or recombination of avian influenza (AI) virus. The greatest concern is that till date, no satisfactory medicine or vaccines are available, leading to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.633283/full |
| _version_ | 1819176772552359936 |
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| author | Aruna Pal Abantika Pal Pradyumna Baviskar |
| author_facet | Aruna Pal Abantika Pal Pradyumna Baviskar |
| author_sort | Aruna Pal |
| collection | DOAJ |
| description | Avian influenza is a disease with every possibility to evolve as a human-to-human pandemic arising out of frequent mutations and genetic reassortment or recombination of avian influenza (AI) virus. The greatest concern is that till date, no satisfactory medicine or vaccines are available, leading to massive culling of poultry birds, causing huge economic loss and ban on export of chicken products, which emphasizes the need to develop an alternative strategy for control of AI. In the current study, we attempt to explore the molecular mechanism of innate immune potential of ducks against avian influenza. In the present study, we have characterized immune response molecules such as duck TLR3, TLR7, and RIGI that are predicted to have potent antiviral activities against the identified strain of avian influenza through in silico studies (molecular docking) followed by experimental validation with differential mRNA expression analysis. Future exploitation may include immunomodulation with the recombinant protein, and transgenic or gene-edited chicken resistant to bird flu. |
| first_indexed | 2024-12-22T21:16:04Z |
| format | Article |
| id | doaj.art-44da817bad6d42ceb9fe363defe7ac52 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-22T21:16:04Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-44da817bad6d42ceb9fe363defe7ac522022-12-21T18:12:21ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-12-01810.3389/fmolb.2021.633283633283RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous DucksAruna Pal0Abantika Pal1Pradyumna Baviskar2West Bengal University of Animal and Fishery Sciences, Kolkata, IndiaIndian Institute of Technology Kharagpur, Kharagpur, IndiaSt. Jude Children’s Research Hospital, Memphis, TN, United StatesAvian influenza is a disease with every possibility to evolve as a human-to-human pandemic arising out of frequent mutations and genetic reassortment or recombination of avian influenza (AI) virus. The greatest concern is that till date, no satisfactory medicine or vaccines are available, leading to massive culling of poultry birds, causing huge economic loss and ban on export of chicken products, which emphasizes the need to develop an alternative strategy for control of AI. In the current study, we attempt to explore the molecular mechanism of innate immune potential of ducks against avian influenza. In the present study, we have characterized immune response molecules such as duck TLR3, TLR7, and RIGI that are predicted to have potent antiviral activities against the identified strain of avian influenza through in silico studies (molecular docking) followed by experimental validation with differential mRNA expression analysis. Future exploitation may include immunomodulation with the recombinant protein, and transgenic or gene-edited chicken resistant to bird flu.https://www.frontiersin.org/articles/10.3389/fmolb.2021.633283/fullAnas platyrhynchosavian influenzaRIGITLR3TLR7 |
| spellingShingle | Aruna Pal Abantika Pal Pradyumna Baviskar RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks Frontiers in Molecular Biosciences Anas platyrhynchos avian influenza RIGI TLR3 TLR7 |
| title | RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks |
| title_full | RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks |
| title_fullStr | RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks |
| title_full_unstemmed | RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks |
| title_short | RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks |
| title_sort | rigi tlr7 and tlr3 genes were predicted to have immune response against avian influenza in indigenous ducks |
| topic | Anas platyrhynchos avian influenza RIGI TLR3 TLR7 |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.633283/full |
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