Fe(III)-doxycycline complexes with diimine ligands: Syntheses, characterization and biological properties
Three new iron(III) complexes of doxycycline viz: [Fe(dox)2Cl]Cl2 (1), [Febpy(dox)Cl]Cl2 (2) and [Fephen(dox)Cl]Cl2 (3), where dox is doxycycline, bpy is 2,2ʹ-bipyridine and phen is 1,10-phenanthroline, were synthesized and characterized by elemental analysis, electronic absorption, FT-IR, and elect...
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| Format: | Article |
| Language: | English |
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Society of Chemists and Technologists of Macedonia
2019-05-01
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| Series: | Macedonian Journal of Chemistry and Chemical Engineering |
| Subjects: | |
| Online Access: | https://mjcce.org.mk/index.php/MJCCE/article/view/1506 |
| _version_ | 1818616420384112640 |
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| author | Joshua A Obaleye Olufunso Olumide Abosede |
| author_facet | Joshua A Obaleye Olufunso Olumide Abosede |
| author_sort | Joshua A Obaleye |
| collection | DOAJ |
| description | Three new iron(III) complexes of doxycycline viz: [Fe(dox)2Cl]Cl2 (1), [Febpy(dox)Cl]Cl2 (2) and [Fephen(dox)Cl]Cl2 (3), where dox is doxycycline, bpy is 2,2ʹ-bipyridine and phen is 1,10-phenanthroline, were synthesized and characterized by elemental analysis, electronic absorption, FT-IR, and electrospray ionization mass spectroscopy. Doxycycline and the polypyridyl ligands behave as bidendate ligands; the polypyridyl ligands coordinate through the two diimine nitrogen atoms and doxycycline through enolate and diketoamide oxygen atoms of ring A in a five-coordinate system with chloride atom in the axial position. Their antibacterial and antiplasmodial activities against chloroquine-sensitive Plasmodium falciparum NF54 and their interaction with calf thymus (CT) DNA using electronic titration were investigated. The three complexes showed good activity against strains of Staphylococcus aureus and Klebsiella pneumonia. The complexes bind moderately to CT DNA with binding constants of 5.6 × 104 and 4.8 × 104 for complexes 2 and 3, respectively. |
| first_indexed | 2024-12-16T16:49:31Z |
| format | Article |
| id | doaj.art-44dadf1383074b2c8d01a299f142c9dd |
| institution | Directory Open Access Journal |
| issn | 1857-5552 1857-5625 |
| language | English |
| last_indexed | 2024-12-16T16:49:31Z |
| publishDate | 2019-05-01 |
| publisher | Society of Chemists and Technologists of Macedonia |
| record_format | Article |
| series | Macedonian Journal of Chemistry and Chemical Engineering |
| spelling | doaj.art-44dadf1383074b2c8d01a299f142c9dd2022-12-21T22:24:04ZengSociety of Chemists and Technologists of MacedoniaMacedonian Journal of Chemistry and Chemical Engineering1857-55521857-56252019-05-01381293810.20450/mjcce.2019.1506392Fe(III)-doxycycline complexes with diimine ligands: Syntheses, characterization and biological propertiesJoshua A Obaleye0Olufunso Olumide Abosede1Department of Chemistry, University of Ilorin, PMB 1515, IlorinDepartment of Chemistry, Federal University, Otuoke, Bayelsa StateThree new iron(III) complexes of doxycycline viz: [Fe(dox)2Cl]Cl2 (1), [Febpy(dox)Cl]Cl2 (2) and [Fephen(dox)Cl]Cl2 (3), where dox is doxycycline, bpy is 2,2ʹ-bipyridine and phen is 1,10-phenanthroline, were synthesized and characterized by elemental analysis, electronic absorption, FT-IR, and electrospray ionization mass spectroscopy. Doxycycline and the polypyridyl ligands behave as bidendate ligands; the polypyridyl ligands coordinate through the two diimine nitrogen atoms and doxycycline through enolate and diketoamide oxygen atoms of ring A in a five-coordinate system with chloride atom in the axial position. Their antibacterial and antiplasmodial activities against chloroquine-sensitive Plasmodium falciparum NF54 and their interaction with calf thymus (CT) DNA using electronic titration were investigated. The three complexes showed good activity against strains of Staphylococcus aureus and Klebsiella pneumonia. The complexes bind moderately to CT DNA with binding constants of 5.6 × 104 and 4.8 × 104 for complexes 2 and 3, respectively.https://mjcce.org.mk/index.php/MJCCE/article/view/1506doxycyclinecomplex, diimine, synthesis, characterization biological activity |
| spellingShingle | Joshua A Obaleye Olufunso Olumide Abosede Fe(III)-doxycycline complexes with diimine ligands: Syntheses, characterization and biological properties Macedonian Journal of Chemistry and Chemical Engineering doxycycline complex, diimine, synthesis, characterization biological activity |
| title | Fe(III)-doxycycline complexes with diimine ligands: Syntheses, characterization and biological properties |
| title_full | Fe(III)-doxycycline complexes with diimine ligands: Syntheses, characterization and biological properties |
| title_fullStr | Fe(III)-doxycycline complexes with diimine ligands: Syntheses, characterization and biological properties |
| title_full_unstemmed | Fe(III)-doxycycline complexes with diimine ligands: Syntheses, characterization and biological properties |
| title_short | Fe(III)-doxycycline complexes with diimine ligands: Syntheses, characterization and biological properties |
| title_sort | fe iii doxycycline complexes with diimine ligands syntheses characterization and biological properties |
| topic | doxycycline complex, diimine, synthesis, characterization biological activity |
| url | https://mjcce.org.mk/index.php/MJCCE/article/view/1506 |
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