Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis
IntroductionOsteoporosis (OP) is primarily diagnosed through bone mineral density (BMD) measurements, and it often leads to fracture. Observational studies suggest that several mental diseases (MDs) may be linked to OP, but the causal direction of these associations remain unclear. This study aims t...
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1125427/full |
| _version_ | 1827964159644401664 |
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| author | Fen Tang Sheng Wang Hongxia Zhao Demeng Xia Xin Dong Xin Dong |
| author_facet | Fen Tang Sheng Wang Hongxia Zhao Demeng Xia Xin Dong Xin Dong |
| author_sort | Fen Tang |
| collection | DOAJ |
| description | IntroductionOsteoporosis (OP) is primarily diagnosed through bone mineral density (BMD) measurements, and it often leads to fracture. Observational studies suggest that several mental diseases (MDs) may be linked to OP, but the causal direction of these associations remain unclear. This study aims to explore the potential causal association between five MDs (Schizophrenia, Depression, Alzheimer's disease, Parkinson's disease, and Epilepsy) and the risk of OP.MethodsFirst, single-nucleotide polymorphisms (SNPs) were filtered from summary-level genome-wide association studies using quality control measures. Subsequently, we employed two-sample Mendelian randomization (MR) analysis to indirectly analyze the causal effect of MDs on the risk of OP through bone mineral density (in total body, femoral neck, lumbar spine, forearm, and heel) and fractures (in leg, arm, heel, spine, and osteoporotic fractures). Lastly, the causal effect of the MDs on the risk of OP was evaluated directly through OP. MR analysis was performed using several methods, including inverse variance weighting (IVW)-random effects, IVW-fixed effects, maximum likelihood, weighted median, MR-Egger regression, and penalized weighted median.ResultsThe results did not show any evidence of a causal relationship between MDs and the risk of OP (with almost all P values > 0.05). The robustness of the above results was proved to be good.DiscussionIn conclusion, this study did not find evidence supporting the claim that MDs have a definitive impact on the risk of OP, which contradicts many existing observational reports. Further studies are needed to determine the potential mechanisms of the associations observed in observational studies. |
| first_indexed | 2024-04-09T17:10:07Z |
| format | Article |
| id | doaj.art-44dd75d362ac43f69a8578476094bd74 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T17:10:07Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-44dd75d362ac43f69a8578476094bd742023-04-20T05:59:30ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11254271125427Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosisFen Tang0Sheng Wang1Hongxia Zhao2Demeng Xia3Xin Dong4Xin Dong5School of Medicine, Shanghai University, Shanghai, ChinaDepartment of Emergency, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaClinical Research Institute of Zhanjiang, Central People’s Hospital of Zhanjiang, Zhanjiang, ChinaLuodian Clinical Drug Research Center, Shanghai Baoshan Luodian Hospital, Shanghai University, Shanghai, ChinaSchool of Medicine, Shanghai University, Shanghai, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, ChinaIntroductionOsteoporosis (OP) is primarily diagnosed through bone mineral density (BMD) measurements, and it often leads to fracture. Observational studies suggest that several mental diseases (MDs) may be linked to OP, but the causal direction of these associations remain unclear. This study aims to explore the potential causal association between five MDs (Schizophrenia, Depression, Alzheimer's disease, Parkinson's disease, and Epilepsy) and the risk of OP.MethodsFirst, single-nucleotide polymorphisms (SNPs) were filtered from summary-level genome-wide association studies using quality control measures. Subsequently, we employed two-sample Mendelian randomization (MR) analysis to indirectly analyze the causal effect of MDs on the risk of OP through bone mineral density (in total body, femoral neck, lumbar spine, forearm, and heel) and fractures (in leg, arm, heel, spine, and osteoporotic fractures). Lastly, the causal effect of the MDs on the risk of OP was evaluated directly through OP. MR analysis was performed using several methods, including inverse variance weighting (IVW)-random effects, IVW-fixed effects, maximum likelihood, weighted median, MR-Egger regression, and penalized weighted median.ResultsThe results did not show any evidence of a causal relationship between MDs and the risk of OP (with almost all P values > 0.05). The robustness of the above results was proved to be good.DiscussionIn conclusion, this study did not find evidence supporting the claim that MDs have a definitive impact on the risk of OP, which contradicts many existing observational reports. Further studies are needed to determine the potential mechanisms of the associations observed in observational studies.https://www.frontiersin.org/articles/10.3389/fendo.2023.1125427/fullmental diseasesosteoporosisosteoporosis fractureMendelian randomizationgenome-wide association study |
| spellingShingle | Fen Tang Sheng Wang Hongxia Zhao Demeng Xia Xin Dong Xin Dong Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis Frontiers in Endocrinology mental diseases osteoporosis osteoporosis fracture Mendelian randomization genome-wide association study |
| title | Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis |
| title_full | Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis |
| title_fullStr | Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis |
| title_full_unstemmed | Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis |
| title_short | Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis |
| title_sort | mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis |
| topic | mental diseases osteoporosis osteoporosis fracture Mendelian randomization genome-wide association study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1125427/full |
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