Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions
Mitochondria are structurally and functionally unique organelles in male gametes. Apparently, as the only organelles remaining in mature sperm, mitochondria not only produce adeno-sine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) to support sperm mobility, but also play key roles in...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/15/5/519 |
| _version_ | 1797496924725575680 |
|---|---|
| author | Jing-Jing Wang Shu-Xia Wang Tehmina Yan Feng Rui-Fen Zhang Xin-Yue Li Qiong Sun Jian Ding |
| author_facet | Jing-Jing Wang Shu-Xia Wang Tehmina Yan Feng Rui-Fen Zhang Xin-Yue Li Qiong Sun Jian Ding |
| author_sort | Jing-Jing Wang |
| collection | DOAJ |
| description | Mitochondria are structurally and functionally unique organelles in male gametes. Apparently, as the only organelles remaining in mature sperm, mitochondria not only produce adeno-sine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) to support sperm mobility, but also play key roles in regulating reactive oxidation species (ROS) signaling, calcium homeostasis, steroid hormone biosynthesis, and apoptosis. Mitochondrial dysfunction is often associated with the aging process. Age-dependent alterations of the epididymis can cause alterations in sperm mitochondrial functioning. The resultant cellular defects in sperm have been implicated in male infertility. Among these, oxidative stress (OS) due to the overproduction of ROS in mitochondria may represent one of the major causes of these disorders. Excessive ROS can trigger DNA damage, disturb calcium homeostasis, impair OXPHOS, disrupt the integrity of the sperm lipid membrane, and induce apoptosis. Given these facts, scavenging ROS by antioxidants hold great potential in terms of finding promising therapeutic strategies to treat male infertility. Here, we summarize the progress made in understanding mitochondrial dysfunction, aging, and male infertility. The clinical potential of antioxidant interventions was also discussed. |
| first_indexed | 2024-03-10T03:10:19Z |
| format | Article |
| id | doaj.art-44df54c5aecd453da012471ab0e668f4 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:10:19Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-44df54c5aecd453da012471ab0e668f42023-11-23T12:33:50ZengMDPI AGPharmaceuticals1424-82472022-04-0115551910.3390/ph15050519Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant InterventionsJing-Jing Wang0Shu-Xia Wang1Tehmina2Yan Feng3Rui-Fen Zhang4Xin-Yue Li5Qiong Sun6Jian Ding7School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaSchool of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaSchool of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaSchool of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaSchool of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaSchool of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaSchool of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaSchool of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaMitochondria are structurally and functionally unique organelles in male gametes. Apparently, as the only organelles remaining in mature sperm, mitochondria not only produce adeno-sine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) to support sperm mobility, but also play key roles in regulating reactive oxidation species (ROS) signaling, calcium homeostasis, steroid hormone biosynthesis, and apoptosis. Mitochondrial dysfunction is often associated with the aging process. Age-dependent alterations of the epididymis can cause alterations in sperm mitochondrial functioning. The resultant cellular defects in sperm have been implicated in male infertility. Among these, oxidative stress (OS) due to the overproduction of ROS in mitochondria may represent one of the major causes of these disorders. Excessive ROS can trigger DNA damage, disturb calcium homeostasis, impair OXPHOS, disrupt the integrity of the sperm lipid membrane, and induce apoptosis. Given these facts, scavenging ROS by antioxidants hold great potential in terms of finding promising therapeutic strategies to treat male infertility. Here, we summarize the progress made in understanding mitochondrial dysfunction, aging, and male infertility. The clinical potential of antioxidant interventions was also discussed.https://www.mdpi.com/1424-8247/15/5/519mitochondriareactive oxidation speciesagingantioxidantmale infertility |
| spellingShingle | Jing-Jing Wang Shu-Xia Wang Tehmina Yan Feng Rui-Fen Zhang Xin-Yue Li Qiong Sun Jian Ding Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions Pharmaceuticals mitochondria reactive oxidation species aging antioxidant male infertility |
| title | Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions |
| title_full | Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions |
| title_fullStr | Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions |
| title_full_unstemmed | Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions |
| title_short | Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions |
| title_sort | age related decline of male fertility mitochondrial dysfunction and the antioxidant interventions |
| topic | mitochondria reactive oxidation species aging antioxidant male infertility |
| url | https://www.mdpi.com/1424-8247/15/5/519 |
| work_keys_str_mv | AT jingjingwang agerelateddeclineofmalefertilitymitochondrialdysfunctionandtheantioxidantinterventions AT shuxiawang agerelateddeclineofmalefertilitymitochondrialdysfunctionandtheantioxidantinterventions AT tehmina agerelateddeclineofmalefertilitymitochondrialdysfunctionandtheantioxidantinterventions AT yanfeng agerelateddeclineofmalefertilitymitochondrialdysfunctionandtheantioxidantinterventions AT ruifenzhang agerelateddeclineofmalefertilitymitochondrialdysfunctionandtheantioxidantinterventions AT xinyueli agerelateddeclineofmalefertilitymitochondrialdysfunctionandtheantioxidantinterventions AT qiongsun agerelateddeclineofmalefertilitymitochondrialdysfunctionandtheantioxidantinterventions AT jianding agerelateddeclineofmalefertilitymitochondrialdysfunctionandtheantioxidantinterventions |