Preparation and Properties of (Sc<sub>2</sub>O<sub>3</sub>-MgO)/Pcl/Pvp Electrospun Nanofiber Membranes for the Inhibition of <i>Escherichia coli</i> Infections

Preparation and Properties of (Sc<sub>2</sub>O<sub>3</sub>-MgO)/Pcl/Pvp Electrospun Nanofiber Membranes for the Inhibition of <i>Escherichia coli</i> Infections

Due to their high porosity, large specific surface area, and structural similarity with the extracellular matrix (ECM), electrospun nanofiber membranes are often endowed with the antibacterial properties for biomedical applications. The purpose of this study was to synthesize nano-structured Sc2O3-M...

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Bibliographic Details
Main Authors: Yanjing Liu, Xiyue Li, Yuezhou Liu, Yaping Huang, Fuming Wang, Yongfang Qian, Ying Wang
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
nano-textured
Sc<sub>2</sub>O<sub>3</sub>-MgO
antibacterial
electrospinning
Online Access:https://www.mdpi.com/1422-0067/24/8/7649
Description
Summary:Due to their high porosity, large specific surface area, and structural similarity with the extracellular matrix (ECM), electrospun nanofiber membranes are often endowed with the antibacterial properties for biomedical applications. The purpose of this study was to synthesize nano-structured Sc2O3-MgO by doping Sc<sup>3+</sup>, calcining at 600 °C, and then loading it onto the PCL/PVP substrates with electrospinning technology with the aim of developing new efficient antibacterial nanofiber membranes for tissue engineering. A scanning electron microscope (SEM) and energy dispersive X-ray spectrometer (EDS) were used to study the morphology of all formulations and analyze the types and contents of the elements, and an X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform attenuated total reflection infrared spectroscopy (ATR-FTIR) were used for further analysis. The experimental results showed that the PCL/PVP (SMCV-2.0) nanofibers loaded with 2.0 wt% Sc<sub>2</sub>O<sub>3</sub>-MgO were smooth and homogeneous with an average diameter of 252.6 nm; the antibacterial test indicated that a low load concentration of 2.0 wt% Sc2O3-MgO in PCL/PVP (SMCV-2.0) showed a 100% antibacterial rate against <i>Escherichia coli</i> (<i>E. coli</i>).
ISSN:1661-6596
1422-0067

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