Rapid biodegradable microneedles with allergen reservoir for skin allergy test
Abstract With the increasing allergy cases worldwide, this study introduces a biodegradable microneedle system to facilitate allergy testing process. Dissolving microneedle provides a minimally invasive manner to go through skin barrier while avoiding needle phobia among patents, especially children...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2020-07-01
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| Series: | Micro and Nano Systems Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40486-020-00114-z |
| _version_ | 1818920195490578432 |
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| author | Le-Giang Tran Woo-Tae Park |
| author_facet | Le-Giang Tran Woo-Tae Park |
| author_sort | Le-Giang Tran |
| collection | DOAJ |
| description | Abstract With the increasing allergy cases worldwide, this study introduces a biodegradable microneedle system to facilitate allergy testing process. Dissolving microneedle provides a minimally invasive manner to go through skin barrier while avoiding needle phobia among patents, especially children. The microneedles were fabricated using copolymer polyvinylpyrrolidone-co-methacrylic acid (PVP-MAA) material. To ensure the successful insertion of microneedles into the skin, we tailored the mechanical strength of the copolymer by adjusting the weight ratio of two constituted polymers. A reservoir was designed to load allergy specimen for the allergy test. This system is expected to offer a simple and effective allergy testing that can facilitate the allergy testing protocol. |
| first_indexed | 2024-12-20T01:17:54Z |
| format | Article |
| id | doaj.art-44e58d3f9e4f46ecb846832839536609 |
| institution | Directory Open Access Journal |
| issn | 2213-9621 |
| language | English |
| last_indexed | 2024-12-20T01:17:54Z |
| publishDate | 2020-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Micro and Nano Systems Letters |
| spelling | doaj.art-44e58d3f9e4f46ecb8468328395366092022-12-21T19:58:32ZengSpringerOpenMicro and Nano Systems Letters2213-96212020-07-01811510.1186/s40486-020-00114-zRapid biodegradable microneedles with allergen reservoir for skin allergy testLe-Giang Tran0Woo-Tae Park1Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and TechnologyConvergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and TechnologyAbstract With the increasing allergy cases worldwide, this study introduces a biodegradable microneedle system to facilitate allergy testing process. Dissolving microneedle provides a minimally invasive manner to go through skin barrier while avoiding needle phobia among patents, especially children. The microneedles were fabricated using copolymer polyvinylpyrrolidone-co-methacrylic acid (PVP-MAA) material. To ensure the successful insertion of microneedles into the skin, we tailored the mechanical strength of the copolymer by adjusting the weight ratio of two constituted polymers. A reservoir was designed to load allergy specimen for the allergy test. This system is expected to offer a simple and effective allergy testing that can facilitate the allergy testing protocol.http://link.springer.com/article/10.1186/s40486-020-00114-zAllergy testingSkin prick testMicroneedlePolyvinylpyrrolidoneMethacrylate acid |
| spellingShingle | Le-Giang Tran Woo-Tae Park Rapid biodegradable microneedles with allergen reservoir for skin allergy test Micro and Nano Systems Letters Allergy testing Skin prick test Microneedle Polyvinylpyrrolidone Methacrylate acid |
| title | Rapid biodegradable microneedles with allergen reservoir for skin allergy test |
| title_full | Rapid biodegradable microneedles with allergen reservoir for skin allergy test |
| title_fullStr | Rapid biodegradable microneedles with allergen reservoir for skin allergy test |
| title_full_unstemmed | Rapid biodegradable microneedles with allergen reservoir for skin allergy test |
| title_short | Rapid biodegradable microneedles with allergen reservoir for skin allergy test |
| title_sort | rapid biodegradable microneedles with allergen reservoir for skin allergy test |
| topic | Allergy testing Skin prick test Microneedle Polyvinylpyrrolidone Methacrylate acid |
| url | http://link.springer.com/article/10.1186/s40486-020-00114-z |
| work_keys_str_mv | AT legiangtran rapidbiodegradablemicroneedleswithallergenreservoirforskinallergytest AT wootaepark rapidbiodegradablemicroneedleswithallergenreservoirforskinallergytest |