Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I

ABSTRACT Stimulation of the antiviral response depends on the sensing of viral pathogen-associated molecular patterns (PAMPs) by specialized cellular proteins. During infection with RNA viruses, 5′-di- or -triphosphates accompanying specific single or double-stranded RNA motifs trigger signaling of...

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Main Authors: Jie Xu, Xiomara Mercado-López, Jennifer T. Grier, Won-keun Kim, Lauren F. Chun, Edward B. Irvine, Yoandris Del Toro Duany, Alison Kell, Sun Hur, Michael Gale, Arjun Raj, Carolina B. López
Format: Article
Language:English
Published: American Society for Microbiology 2015-10-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01265-15

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