Ancestry-specific polygenic risk scores are risk enhancers for clinical cardiovascular disease assessments

Ancestry-specific polygenic risk scores are risk enhancers for clinical cardiovascular disease assessments

Abstract Clinical implementation of new prediction models requires evaluation of their utility in a broad range of intended use populations. Here we develop and validate ancestry-specific Polygenic Risk Scores (PRSs) for Coronary Artery Disease (CAD) using 29,389 individuals from diverse cohorts and...

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Bibliographic Details
Main Authors: George B. Busby, Scott Kulm, Alessandro Bolli, Jen Kintzle, Paolo Di Domenico, Giordano Bottà
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42897-w

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