Programmable Paper-Based Microfluidic Devices for Biomarker Detections
Recent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide range of biomarker detection with high sensitivity...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/10/8/516 |
| _version_ | 1811287922294390784 |
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| author | Veasna Soum Sooyong Park Albertus Ivan Brilian Oh-Sun Kwon Kwanwoo Shin |
| author_facet | Veasna Soum Sooyong Park Albertus Ivan Brilian Oh-Sun Kwon Kwanwoo Shin |
| author_sort | Veasna Soum |
| collection | DOAJ |
| description | Recent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide range of biomarker detection with high sensitivity and automation for single- and multi-step assays because they provide better control for manipulating fluid samples. In this review, we examine the advances in programmable microfluidics, i.e., paper-based continuous-flow microfluidic (p-CMF) devices and paper-based digital microfluidic (p-DMF) devices, for biomarker detection. First, we discuss the methods used to fabricate these two types of paper-based microfluidic devices and the strategies for programming fluid delivery and for droplet manipulation. Next, we discuss the use of these programmable paper-based devices for the single- and multi-step detection of biomarkers. Finally, we present the current limitations of paper-based microfluidics for biomarker detection and the outlook for their development. |
| first_indexed | 2024-04-13T03:27:02Z |
| format | Article |
| id | doaj.art-44ea1c141af04ad49a92a92b37620d18 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-04-13T03:27:02Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-44ea1c141af04ad49a92a92b37620d182022-12-22T03:04:37ZengMDPI AGMicromachines2072-666X2019-08-0110851610.3390/mi10080516mi10080516Programmable Paper-Based Microfluidic Devices for Biomarker DetectionsVeasna Soum0Sooyong Park1Albertus Ivan Brilian2Oh-Sun Kwon3Kwanwoo Shin4Department of Chemistry, Institute of Biological Interfaces, Sogang University, Seoul 04107, KoreaDepartment of Chemistry, Institute of Biological Interfaces, Sogang University, Seoul 04107, KoreaDepartment of Chemistry, Institute of Biological Interfaces, Sogang University, Seoul 04107, KoreaDepartment of Chemistry, Institute of Biological Interfaces, Sogang University, Seoul 04107, KoreaDepartment of Chemistry, Institute of Biological Interfaces, Sogang University, Seoul 04107, KoreaRecent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide range of biomarker detection with high sensitivity and automation for single- and multi-step assays because they provide better control for manipulating fluid samples. In this review, we examine the advances in programmable microfluidics, i.e., paper-based continuous-flow microfluidic (p-CMF) devices and paper-based digital microfluidic (p-DMF) devices, for biomarker detection. First, we discuss the methods used to fabricate these two types of paper-based microfluidic devices and the strategies for programming fluid delivery and for droplet manipulation. Next, we discuss the use of these programmable paper-based devices for the single- and multi-step detection of biomarkers. Finally, we present the current limitations of paper-based microfluidics for biomarker detection and the outlook for their development.https://www.mdpi.com/2072-666X/10/8/516paper-based microfluidic deviceflow controldroplet actuationmulti-step assaybiomarker detectiondigital microfluidic device |
| spellingShingle | Veasna Soum Sooyong Park Albertus Ivan Brilian Oh-Sun Kwon Kwanwoo Shin Programmable Paper-Based Microfluidic Devices for Biomarker Detections Micromachines paper-based microfluidic device flow control droplet actuation multi-step assay biomarker detection digital microfluidic device |
| title | Programmable Paper-Based Microfluidic Devices for Biomarker Detections |
| title_full | Programmable Paper-Based Microfluidic Devices for Biomarker Detections |
| title_fullStr | Programmable Paper-Based Microfluidic Devices for Biomarker Detections |
| title_full_unstemmed | Programmable Paper-Based Microfluidic Devices for Biomarker Detections |
| title_short | Programmable Paper-Based Microfluidic Devices for Biomarker Detections |
| title_sort | programmable paper based microfluidic devices for biomarker detections |
| topic | paper-based microfluidic device flow control droplet actuation multi-step assay biomarker detection digital microfluidic device |
| url | https://www.mdpi.com/2072-666X/10/8/516 |
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