The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty.
Aseptic loosening is a major cause of revision surgery of total hip arthroplasty (THA). Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4755546?pdf=render |
| _version_ | 1828325794996289536 |
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| author | Patrick Stelmach Christian Wedemeyer Lena Fuest Gina Kurscheid Thorsten Gehrke Stefanie Klenke Marcus Jäger Max D Kauther Hagen S Bachmann |
| author_facet | Patrick Stelmach Christian Wedemeyer Lena Fuest Gina Kurscheid Thorsten Gehrke Stefanie Klenke Marcus Jäger Max D Kauther Hagen S Bachmann |
| author_sort | Patrick Stelmach |
| collection | DOAJ |
| description | Aseptic loosening is a major cause of revision surgery of total hip arthroplasty (THA). Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine whether the functional single nucleotide polymorphism (SNP) c.-938C>A (rs2279115), located in the promoter region of the BCL2 gene has an impact on aseptic loosening of THA we genotyped and analyzed 234 patients suffering from aseptic loosening and 231 patients after primary THA. The polymorphism is associated with risk for aseptic loosening with the CC genotype at highest risk for aseptic loosening, Odds Ratio CC vs. AA 1.93, 95%CI 1.15-3.25, p = 0.013. In contrast, low risk AA genotype carriers that still developed aseptic loosening showed a significantly shorter time to aseptic loosening than patients carrying the C allele (p = 0.004). These results indicate that the BCL2 -938C>A polymorphism influences the occurrence and course of aseptic loosening and suggests this polymorphism as an interesting candidate for prospective studies and analyses in THA registers. |
| first_indexed | 2024-04-13T19:27:47Z |
| format | Article |
| id | doaj.art-44eafa1e139443cf8cf2b6ab0a0de712 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T19:27:47Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-44eafa1e139443cf8cf2b6ab0a0de7122022-12-22T02:33:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014952810.1371/journal.pone.0149528The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty.Patrick StelmachChristian WedemeyerLena FuestGina KurscheidThorsten GehrkeStefanie KlenkeMarcus JägerMax D KautherHagen S BachmannAseptic loosening is a major cause of revision surgery of total hip arthroplasty (THA). Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine whether the functional single nucleotide polymorphism (SNP) c.-938C>A (rs2279115), located in the promoter region of the BCL2 gene has an impact on aseptic loosening of THA we genotyped and analyzed 234 patients suffering from aseptic loosening and 231 patients after primary THA. The polymorphism is associated with risk for aseptic loosening with the CC genotype at highest risk for aseptic loosening, Odds Ratio CC vs. AA 1.93, 95%CI 1.15-3.25, p = 0.013. In contrast, low risk AA genotype carriers that still developed aseptic loosening showed a significantly shorter time to aseptic loosening than patients carrying the C allele (p = 0.004). These results indicate that the BCL2 -938C>A polymorphism influences the occurrence and course of aseptic loosening and suggests this polymorphism as an interesting candidate for prospective studies and analyses in THA registers.http://europepmc.org/articles/PMC4755546?pdf=render |
| spellingShingle | Patrick Stelmach Christian Wedemeyer Lena Fuest Gina Kurscheid Thorsten Gehrke Stefanie Klenke Marcus Jäger Max D Kauther Hagen S Bachmann The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty. PLoS ONE |
| title | The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty. |
| title_full | The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty. |
| title_fullStr | The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty. |
| title_full_unstemmed | The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty. |
| title_short | The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty. |
| title_sort | bcl2 938c a promoter polymorphism is associated with risk for and time to aseptic loosening of total hip arthroplasty |
| url | http://europepmc.org/articles/PMC4755546?pdf=render |
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