Grey matter alterations in post-traumatic stress disorder, obsessive–compulsive disorder and social anxiety disorder
Post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD) and social anxiety disorder (SAD) all bear the core symptom of anxiety and are separately classified in the new DSM-5 system. The aim of the present study is to obtain evidence for neuroanatomical difference for these disorde...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00219/full |
| _version_ | 1828472732780593152 |
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| author | Bochao eCheng Xiaoqi eHuang Shiguang eLi Xinyu eHu Ya eLuo Xiuli eWang Xun eYang Changjian eQiu Yanchun eYang Wei eZhang Feng eBi Neil eRoberts Qiyong eGong |
| author_facet | Bochao eCheng Xiaoqi eHuang Shiguang eLi Xinyu eHu Ya eLuo Xiuli eWang Xun eYang Changjian eQiu Yanchun eYang Wei eZhang Feng eBi Neil eRoberts Qiyong eGong |
| author_sort | Bochao eCheng |
| collection | DOAJ |
| description | Post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD) and social anxiety disorder (SAD) all bear the core symptom of anxiety and are separately classified in the new DSM-5 system. The aim of the present study is to obtain evidence for neuroanatomical difference for these disorders. We applied voxel-based morphometry (VBM) with Diffeomorphic Anatomic Registration Through Exponentiated Lie (DARTEL) to compare grey matter volume (GMV) in Magnetic Resonance (MR) images obtained for thirty patients with PTSD, twenty nine patients with OCD, twenty patients with SAD and thirty healthy controls. GMV across all four groups differed in left hypothalamus and left inferior parietal lobule and post hoc analyses revealed that this difference is primarily due to reduced GMV in the PTSD group relative to the other groups. Further analysis revealed that the PTSD group also showed reduced GMV in frontal lobe, temporal lobe and cerebellum compared to the OCD group, and reduced GMV in frontal lobes bilaterally compared to SAD group. A significant negative correlation with anxiety symptoms is observed for GMV in left hypothalamus in three disorder groups. We have thus found evidence for brain structure differences that in future could provide biomarkers to potentially support classification of these disorders using MRI. |
| first_indexed | 2024-12-11T05:34:03Z |
| format | Article |
| id | doaj.art-44ec0cae60d54c40a03d34f80fbe1b4d |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-11T05:34:03Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-44ec0cae60d54c40a03d34f80fbe1b4d2022-12-22T01:19:20ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532015-08-01910.3389/fnbeh.2015.00219146431Grey matter alterations in post-traumatic stress disorder, obsessive–compulsive disorder and social anxiety disorderBochao eCheng0Xiaoqi eHuang1Shiguang eLi2Xinyu eHu3Ya eLuo4Xiuli eWang5Xun eYang6Changjian eQiu7Yanchun eYang8Wei eZhang9Feng eBi10Neil eRoberts11Qiyong eGong12West China Hospital of Sichuan UniversiytWest China Hospital of Sichuan UniversiytWest China Hospital of Sichuan UniversiytWest China Hospital of Sichuan UniversiytDepartment of Psychiatry, West China Hospital of Sichuan UniversityDepartment of Psychiatry, West China Hospital of Sichuan UniversityDepartment of Psychiatry, West China Hospital of Sichuan UniversityDepartment of Psychiatry, West China Hospital of Sichuan UniversityDepartment of Psychiatry, West China Hospital of Sichuan UniversityDepartment of Psychiatry, West China Hospital of Sichuan UniversityDepartment of Oncology, West China Hospital of Sichuan UniversityUniversity of EdinburghWest China Hospital of Sichuan UniversiytPost-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD) and social anxiety disorder (SAD) all bear the core symptom of anxiety and are separately classified in the new DSM-5 system. The aim of the present study is to obtain evidence for neuroanatomical difference for these disorders. We applied voxel-based morphometry (VBM) with Diffeomorphic Anatomic Registration Through Exponentiated Lie (DARTEL) to compare grey matter volume (GMV) in Magnetic Resonance (MR) images obtained for thirty patients with PTSD, twenty nine patients with OCD, twenty patients with SAD and thirty healthy controls. GMV across all four groups differed in left hypothalamus and left inferior parietal lobule and post hoc analyses revealed that this difference is primarily due to reduced GMV in the PTSD group relative to the other groups. Further analysis revealed that the PTSD group also showed reduced GMV in frontal lobe, temporal lobe and cerebellum compared to the OCD group, and reduced GMV in frontal lobes bilaterally compared to SAD group. A significant negative correlation with anxiety symptoms is observed for GMV in left hypothalamus in three disorder groups. We have thus found evidence for brain structure differences that in future could provide biomarkers to potentially support classification of these disorders using MRI.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00219/fullObsessive-Compulsive DisorderAnxiety disordergrey matter volumeSocial Anxiety DisorderPost-Traumatic Stress Disorders |
| spellingShingle | Bochao eCheng Xiaoqi eHuang Shiguang eLi Xinyu eHu Ya eLuo Xiuli eWang Xun eYang Changjian eQiu Yanchun eYang Wei eZhang Feng eBi Neil eRoberts Qiyong eGong Grey matter alterations in post-traumatic stress disorder, obsessive–compulsive disorder and social anxiety disorder Frontiers in Behavioral Neuroscience Obsessive-Compulsive Disorder Anxiety disorder grey matter volume Social Anxiety Disorder Post-Traumatic Stress Disorders |
| title | Grey matter alterations in post-traumatic stress disorder, obsessive–compulsive disorder and social anxiety disorder |
| title_full | Grey matter alterations in post-traumatic stress disorder, obsessive–compulsive disorder and social anxiety disorder |
| title_fullStr | Grey matter alterations in post-traumatic stress disorder, obsessive–compulsive disorder and social anxiety disorder |
| title_full_unstemmed | Grey matter alterations in post-traumatic stress disorder, obsessive–compulsive disorder and social anxiety disorder |
| title_short | Grey matter alterations in post-traumatic stress disorder, obsessive–compulsive disorder and social anxiety disorder |
| title_sort | grey matter alterations in post traumatic stress disorder obsessive compulsive disorder and social anxiety disorder |
| topic | Obsessive-Compulsive Disorder Anxiety disorder grey matter volume Social Anxiety Disorder Post-Traumatic Stress Disorders |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00219/full |
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