Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation
Although numerous studies have used systemic approaches to identify prognostic predictors in oral squamous cell carcinoma (OSCC), the effectiveness of these approaches has not been assessed clinically. Further, the mechanism underlying malignant behaviors in OSCC is poorly characterized. This study...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Molecular Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/1878-0261.13328 |
| _version_ | 1797961269022556160 |
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| author | Joo Kyung Noh Seon Rang Woo Moonkyoo Kong Min Kyeong Lee Jung Woo Lee Young Chan Lee Seong‐Gyu Ko Young‐Gyu Eun |
| author_facet | Joo Kyung Noh Seon Rang Woo Moonkyoo Kong Min Kyeong Lee Jung Woo Lee Young Chan Lee Seong‐Gyu Ko Young‐Gyu Eun |
| author_sort | Joo Kyung Noh |
| collection | DOAJ |
| description | Although numerous studies have used systemic approaches to identify prognostic predictors in oral squamous cell carcinoma (OSCC), the effectiveness of these approaches has not been assessed clinically. Further, the mechanism underlying malignant behaviors in OSCC is poorly characterized. This study aimed to develop and verify accurate prognostic predictors for OSCC patients and assess the associated biology. We identified an OSCC‐recurrence‐related gene signature (ORGS) using a Cox regression analysis. Functional enrichment analysis was used to identify enriched pathways and biological processes to reveal the underlying mechanism of OSCC malignant behavior. The ORGS successfully divided OSCC patients into low‐ and high‐risk groups with significantly different overall survivals. Pathway analysis revealed oxidative phosphorylation (OXPHOS) as a signaling pathway associated with the ORGS in OSCC. Interestingly, high OXPHOS status was strongly associated with poor overall survival in OSCC patients. Mediator complex subunit 30 (MED30) was a predicted upstream regulator of OXPHOS, and knockdown of MED30 reduced histone acetylation. We identified that the ORGS was strongly correlated with OXPHOS regulatory processes, suggesting OXPHOS as a key mechanism leading to poor prognosis in OSCC. |
| first_indexed | 2024-04-11T00:56:22Z |
| format | Article |
| id | doaj.art-44ec1059df5b4e028e6ad23be021ce59 |
| institution | Directory Open Access Journal |
| issn | 1574-7891 1878-0261 |
| language | English |
| last_indexed | 2024-04-11T00:56:22Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj.art-44ec1059df5b4e028e6ad23be021ce592023-01-05T03:41:34ZengWileyMolecular Oncology1574-78911878-02612023-01-0117113414910.1002/1878-0261.13328Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylationJoo Kyung Noh0Seon Rang Woo1Moonkyoo Kong2Min Kyeong Lee3Jung Woo Lee4Young Chan Lee5Seong‐Gyu Ko6Young‐Gyu Eun7Department of Biomedical Science and Technology, Graduate School Kyung Hee University Seoul KoreaDepartment of Otolaryngology‐Head & Neck Surgery, Kyung Hee University School of Medicine Kyung Hee University Medical Center Seoul KoreaDepartment of Radiation Oncology, Kyung Hee University School of Medicine Kyung Hee University Medical Center Seoul KoreaDepartment of Biomedical Science and Technology, Graduate School Kyung Hee University Seoul KoreaDepartment of Oral and Maxillofacial Surgery, School of Dentistry Kyung Hee University Seoul KoreaDepartment of Otolaryngology‐Head & Neck Surgery, Kyung Hee University School of Medicine Kyung Hee University Medical Center Seoul KoreaDepartment of Preventive Medicine, College of Korean Medicine Kyung Hee University Seoul KoreaDepartment of Biomedical Science and Technology, Graduate School Kyung Hee University Seoul KoreaAlthough numerous studies have used systemic approaches to identify prognostic predictors in oral squamous cell carcinoma (OSCC), the effectiveness of these approaches has not been assessed clinically. Further, the mechanism underlying malignant behaviors in OSCC is poorly characterized. This study aimed to develop and verify accurate prognostic predictors for OSCC patients and assess the associated biology. We identified an OSCC‐recurrence‐related gene signature (ORGS) using a Cox regression analysis. Functional enrichment analysis was used to identify enriched pathways and biological processes to reveal the underlying mechanism of OSCC malignant behavior. The ORGS successfully divided OSCC patients into low‐ and high‐risk groups with significantly different overall survivals. Pathway analysis revealed oxidative phosphorylation (OXPHOS) as a signaling pathway associated with the ORGS in OSCC. Interestingly, high OXPHOS status was strongly associated with poor overall survival in OSCC patients. Mediator complex subunit 30 (MED30) was a predicted upstream regulator of OXPHOS, and knockdown of MED30 reduced histone acetylation. We identified that the ORGS was strongly correlated with OXPHOS regulatory processes, suggesting OXPHOS as a key mechanism leading to poor prognosis in OSCC.https://doi.org/10.1002/1878-0261.13328gene signatureMED30mitochondrial membrane potentialoral squamous cell carcinomaoxidative phosphorylation |
| spellingShingle | Joo Kyung Noh Seon Rang Woo Moonkyoo Kong Min Kyeong Lee Jung Woo Lee Young Chan Lee Seong‐Gyu Ko Young‐Gyu Eun Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation Molecular Oncology gene signature MED30 mitochondrial membrane potential oral squamous cell carcinoma oxidative phosphorylation |
| title | Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation |
| title_full | Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation |
| title_fullStr | Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation |
| title_full_unstemmed | Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation |
| title_short | Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation |
| title_sort | gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation |
| topic | gene signature MED30 mitochondrial membrane potential oral squamous cell carcinoma oxidative phosphorylation |
| url | https://doi.org/10.1002/1878-0261.13328 |
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