Anthrax lethal toxin disrupts intestinal barrier function and causes systemic infections with enteric bacteria.

Anthrax lethal toxin disrupts intestinal barrier function and causes systemic infections with enteric bacteria.

A variety of intestinal pathogens have virulence factors that target mitogen activated protein kinase (MAPK) signaling pathways, including Bacillus anthracis. Anthrax lethal toxin (LT) has specific proteolytic activity against the upstream regulators of MAPKs, the MAPK kinases (MKKs). Using a murine...

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Bibliographic Details
Main Authors: Chen Sun, Hui Fang, Tao Xie, Roger D Auth, Nayana Patel, Patrick R Murray, Philip J Snoy, David M Frucht
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3306423?pdf=render

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