Partial loss in septo-hippocampal cholinergic neurons alters memory-dependent measures of brain connectivity without overt memory deficits

Partial loss in septo-hippocampal cholinergic neurons alters memory-dependent measures of brain connectivity without overt memory deficits

The functional relevance of septo-hippocampal cholinergic (SHC) degeneration to the degradation of hippocampus-dependent declarative memory (DM) in aging and Alzheimer's disease (AD) remains ill-defined. Specifically, selective SHC lesions often fail to induce overt memory impairments in animal...

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Bibliographic Details
Main Authors:	Laurent Brayda-Bruno, Nicole Mons, Benjamin K. Yee, Jacques Micheau, Djoher Nora Abrous, Xavier Nogues, Aline Marighetto
Format:	Article
Language:	English
Published:	Elsevier 2013-06-01
Series:	Neurobiology of Disease
Subjects:	Declarative memory Aging P75 saporin immunotoxin Radial arm maze Fos immunohistochemistry Functional connectivity
Online Access:	http://www.sciencedirect.com/science/article/pii/S096999611300034X

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