Lung Ultrasound Effectively Detects HIV-Associated Interstitial Pulmonary Disease
Objectives To prospectively evaluate lung ultrasound in comparison with radiography and computed tomography (CT) for detecting HIV-related lung diseases.Methods Ultrasound examinations in HIV-positive patients were evaluated by three raters; available conventional imaging was evaluated by another ra...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221006639 |
| _version_ | 1818356008863399936 |
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| author | Daniel T. Marggrander Sinem Koç-Günel Nesrin Tekeli-Camcı Simon Martin Rejane Golbach Timo Wolf |
| author_facet | Daniel T. Marggrander Sinem Koç-Günel Nesrin Tekeli-Camcı Simon Martin Rejane Golbach Timo Wolf |
| author_sort | Daniel T. Marggrander |
| collection | DOAJ |
| description | Objectives To prospectively evaluate lung ultrasound in comparison with radiography and computed tomography (CT) for detecting HIV-related lung diseases.Methods Ultrasound examinations in HIV-positive patients were evaluated by three raters; available conventional imaging was evaluated by another rater. Results were compared with each other and the definite diagnosis. Interrater reliability was calculated for each finding.Results Eighty HIV-positive patients received lung ultrasound examinations; 74 received conventional imaging. The overall sensitivity was 97.5% for CT, 90.7% for ultrasound and 78.1% for radiography. The most common diagnoses were Pneumocystis jirovecii pneumonia (21 cases) and bacterial pneumonia (17 cases). The most frequent and sensitive ultrasonographic findings were interstitial abnormalities indicated by B-lines, independent of the aetiology. Interrater reliability was high for interstitial abnormalities (ICC=0.82). The interrater reliability for consolidations and effusion increased during the study (r=0.88 and r=0.37, respectively).Conclusions Ultrasound is a fast, reliable and sensitive point-of-care tool, particularly in detecting interstitial lung disease, which is common in HIV-associated illness. It does not effectively discriminate between different aetiologies. A longer learning period might be required to reliably identify consolidations and effusions. |
| first_indexed | 2024-12-13T19:50:23Z |
| format | Article |
| id | doaj.art-44eeeb506b64424a850d3320d0e701d2 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-13T19:50:23Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-44eeeb506b64424a850d3320d0e701d22022-12-21T23:33:26ZengElsevierInternational Journal of Infectious Diseases1201-97122021-10-01111204210Lung Ultrasound Effectively Detects HIV-Associated Interstitial Pulmonary DiseaseDaniel T. Marggrander0Sinem Koç-Günel1Nesrin Tekeli-Camcı2Simon Martin3Rejane Golbach4Timo Wolf5Faculty of Medicine, J.W. Goethe University, Frankfurt, Germany; Correspondence to: Daniel T. Marggrander, Faculty of Medicine, J.W. Goethe University, Theodor-Stern-Kai 7, H33C (Infectious Diseases), 60590 Frankfurt, GermanyInternal Medicine I, Department of Respiratory Medicine and Allergology, University Hospital Frankfurt, GermanyUniversity Thoracic Centre, Department of Oncological Pneumology, St. Elisabethen Hospital Frankfurt, GermanyInstitute of Diagnostic and Interventional Radiology, University Hospital Frankfurt, GermanyInstitute of Biostatistics and Mathematic Modelling, University Hospital Frankfurt, GermanyInternal Medicine II, Department of Infectious Diseases, University Hospital Frankfurt, GermanyObjectives To prospectively evaluate lung ultrasound in comparison with radiography and computed tomography (CT) for detecting HIV-related lung diseases.Methods Ultrasound examinations in HIV-positive patients were evaluated by three raters; available conventional imaging was evaluated by another rater. Results were compared with each other and the definite diagnosis. Interrater reliability was calculated for each finding.Results Eighty HIV-positive patients received lung ultrasound examinations; 74 received conventional imaging. The overall sensitivity was 97.5% for CT, 90.7% for ultrasound and 78.1% for radiography. The most common diagnoses were Pneumocystis jirovecii pneumonia (21 cases) and bacterial pneumonia (17 cases). The most frequent and sensitive ultrasonographic findings were interstitial abnormalities indicated by B-lines, independent of the aetiology. Interrater reliability was high for interstitial abnormalities (ICC=0.82). The interrater reliability for consolidations and effusion increased during the study (r=0.88 and r=0.37, respectively).Conclusions Ultrasound is a fast, reliable and sensitive point-of-care tool, particularly in detecting interstitial lung disease, which is common in HIV-associated illness. It does not effectively discriminate between different aetiologies. A longer learning period might be required to reliably identify consolidations and effusions.http://www.sciencedirect.com/science/article/pii/S1201971221006639AIDSPneumocystis jiroveciiPneumoniaSonographyPoint of care |
| spellingShingle | Daniel T. Marggrander Sinem Koç-Günel Nesrin Tekeli-Camcı Simon Martin Rejane Golbach Timo Wolf Lung Ultrasound Effectively Detects HIV-Associated Interstitial Pulmonary Disease International Journal of Infectious Diseases AIDS Pneumocystis jirovecii Pneumonia Sonography Point of care |
| title | Lung Ultrasound Effectively Detects HIV-Associated Interstitial Pulmonary Disease |
| title_full | Lung Ultrasound Effectively Detects HIV-Associated Interstitial Pulmonary Disease |
| title_fullStr | Lung Ultrasound Effectively Detects HIV-Associated Interstitial Pulmonary Disease |
| title_full_unstemmed | Lung Ultrasound Effectively Detects HIV-Associated Interstitial Pulmonary Disease |
| title_short | Lung Ultrasound Effectively Detects HIV-Associated Interstitial Pulmonary Disease |
| title_sort | lung ultrasound effectively detects hiv associated interstitial pulmonary disease |
| topic | AIDS Pneumocystis jirovecii Pneumonia Sonography Point of care |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221006639 |
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