1,25-Dihydroxyvitamin D inhibits hepatic diacyglycerol accumulation and ameliorates metabolic dysfunction in polycystic ovary syndrome rat models

1,25-Dihydroxyvitamin D inhibits hepatic diacyglycerol accumulation and ameliorates metabolic dysfunction in polycystic ovary syndrome rat models

Introduction: We aimed to evaluate the influence of 1,25-dihydroxyvitamin D (1,25(OH)2D) on metabolic dysfunction and elucidate its underlying mechanism using a rat model of polycystic ovary syndrome (PCOS).Methods: Twenty-four Sprague-Dawley rats were randomly divided into four groups: control grou...

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Bibliographic Details
Main Authors: Xin Yuan, Jianshu Yang, Danlin Sun, Kaiming Luo, Xiaohong Jiang, Long Wang, Shoukui Xiang, Yijie Jiang, Kele Ge, Zhiyang Zhou, Bowen Li, Fei Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
vitamin D
polycystic ovary syndrome
metabolic dysfunction
lipidomics
diacyglycerol
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1077014/full

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