Epigenetic aging of the demographically non-aging naked mole-rat
The exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-27959-9 |
| _version_ | 1819261504469336064 |
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| author | Csaba Kerepesi Margarita V. Meer Julia Ablaeva Vince G. Amoroso Sang-Goo Lee Bohan Zhang Maxim V. Gerashchenko Alexandre Trapp Sun Hee Yim Ake T. Lu Morgan E. Levine Andrei Seluanov Steve Horvath Thomas J. Park Vera Gorbunova Vadim N. Gladyshev |
| author_facet | Csaba Kerepesi Margarita V. Meer Julia Ablaeva Vince G. Amoroso Sang-Goo Lee Bohan Zhang Maxim V. Gerashchenko Alexandre Trapp Sun Hee Yim Ake T. Lu Morgan E. Levine Andrei Seluanov Steve Horvath Thomas J. Park Vera Gorbunova Vadim N. Gladyshev |
| author_sort | Csaba Kerepesi |
| collection | DOAJ |
| description | The exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate. |
| first_indexed | 2024-12-23T19:42:51Z |
| format | Article |
| id | doaj.art-44f348039b714784b3968f7be0bc9284 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T19:42:51Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-44f348039b714784b3968f7be0bc92842022-12-21T17:33:37ZengNature PortfolioNature Communications2041-17232022-01-0113111010.1038/s41467-022-27959-9Epigenetic aging of the demographically non-aging naked mole-ratCsaba Kerepesi0Margarita V. Meer1Julia Ablaeva2Vince G. Amoroso3Sang-Goo Lee4Bohan Zhang5Maxim V. Gerashchenko6Alexandre Trapp7Sun Hee Yim8Ake T. Lu9Morgan E. Levine10Andrei Seluanov11Steve Horvath12Thomas J. Park13Vera Gorbunova14Vadim N. Gladyshev15Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDepartments of Biology and Medicine, University of RochesterLaboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at ChicagoDivision of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Human Genetics, David Geffen School of Medicine, University of CaliforniaDepartment of Pathology, Yale School of MedicineDepartments of Biology and Medicine, University of RochesterDepartment of Human Genetics, David Geffen School of Medicine, University of CaliforniaLaboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at ChicagoDepartments of Biology and Medicine, University of RochesterDivision of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolThe exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate.https://doi.org/10.1038/s41467-022-27959-9 |
| spellingShingle | Csaba Kerepesi Margarita V. Meer Julia Ablaeva Vince G. Amoroso Sang-Goo Lee Bohan Zhang Maxim V. Gerashchenko Alexandre Trapp Sun Hee Yim Ake T. Lu Morgan E. Levine Andrei Seluanov Steve Horvath Thomas J. Park Vera Gorbunova Vadim N. Gladyshev Epigenetic aging of the demographically non-aging naked mole-rat Nature Communications |
| title | Epigenetic aging of the demographically non-aging naked mole-rat |
| title_full | Epigenetic aging of the demographically non-aging naked mole-rat |
| title_fullStr | Epigenetic aging of the demographically non-aging naked mole-rat |
| title_full_unstemmed | Epigenetic aging of the demographically non-aging naked mole-rat |
| title_short | Epigenetic aging of the demographically non-aging naked mole-rat |
| title_sort | epigenetic aging of the demographically non aging naked mole rat |
| url | https://doi.org/10.1038/s41467-022-27959-9 |
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