DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN
<p>Sustained release tablets containing solid dispersions granules of a poorly water soluble drug were prepared to investigate the controlled release of the drug. Baclofen was chosen because of its poor water solubility and short elimination half-life. Poloxamer 188 and PEG 6000 were used as s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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El Oued University
2015-07-01
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| Series: | Journal of Fundamental and Applied Sciences |
| Subjects: | |
| Online Access: | http://jfas.info/index.php/jfas/article/view/87 |
| _version_ | 1818155014791626752 |
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| author | K. H. Janardhana R. Deveswaran S. Bharath B. V. Basavaraj V. Madhavan |
| author_facet | K. H. Janardhana R. Deveswaran S. Bharath B. V. Basavaraj V. Madhavan |
| author_sort | K. H. Janardhana |
| collection | DOAJ |
| description | <p>Sustained release tablets containing solid dispersions granules of a poorly water soluble drug were prepared to investigate the controlled release of the drug. Baclofen was chosen because of its poor water solubility and short elimination half-life. Poloxamer 188 and PEG 6000 were used as solid dispersion carrier. Free flowing solid dispersion granules were prepared by adsorbing the melt of the drug and carriers onto the surface of an adsorbent, Carbopol 934P followed by direct compression with HPMC K4M and HPMC K100 to obtain an solid dispersion loaded sustained release tablets. FTIR studies confirmed that the compatibility of drug and carriers. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) revealed partially amorphous structures of the drug in solid dispersion granules. The solid dispersion granules dissolved completely within 30 min, which was much faster than that of pure drug baclofen. The sustained release of baclofen from the solid dispersion containing tablet was achieved for 2 h in gastric fluid (pH 1.2) and for up to 10 h in intestinal fluid (pH 6.8). A combination of solid dispersion techniques using adsorption and sustained release concepts is a promising approach to control the release rate of poorly water-soluble drugs.</p> |
| first_indexed | 2024-12-11T14:35:40Z |
| format | Article |
| id | doaj.art-44f3eb0873d3483197374473319e4b66 |
| institution | Directory Open Access Journal |
| issn | 1112-9867 |
| language | English |
| last_indexed | 2024-12-11T14:35:40Z |
| publishDate | 2015-07-01 |
| publisher | El Oued University |
| record_format | Article |
| series | Journal of Fundamental and Applied Sciences |
| spelling | doaj.art-44f3eb0873d3483197374473319e4b662022-12-22T01:02:11ZengEl Oued UniversityJournal of Fundamental and Applied Sciences1112-98672015-07-015222023910.4314/jfas.v5i2.1065DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFENK. H. JanardhanaR. DeveswaranS. BharathB. V. BasavarajV. Madhavan<p>Sustained release tablets containing solid dispersions granules of a poorly water soluble drug were prepared to investigate the controlled release of the drug. Baclofen was chosen because of its poor water solubility and short elimination half-life. Poloxamer 188 and PEG 6000 were used as solid dispersion carrier. Free flowing solid dispersion granules were prepared by adsorbing the melt of the drug and carriers onto the surface of an adsorbent, Carbopol 934P followed by direct compression with HPMC K4M and HPMC K100 to obtain an solid dispersion loaded sustained release tablets. FTIR studies confirmed that the compatibility of drug and carriers. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) revealed partially amorphous structures of the drug in solid dispersion granules. The solid dispersion granules dissolved completely within 30 min, which was much faster than that of pure drug baclofen. The sustained release of baclofen from the solid dispersion containing tablet was achieved for 2 h in gastric fluid (pH 1.2) and for up to 10 h in intestinal fluid (pH 6.8). A combination of solid dispersion techniques using adsorption and sustained release concepts is a promising approach to control the release rate of poorly water-soluble drugs.</p>http://jfas.info/index.php/jfas/article/view/87Solid dispersionbaclofensustained releaseadsorbent. |
| spellingShingle | K. H. Janardhana R. Deveswaran S. Bharath B. V. Basavaraj V. Madhavan DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN Journal of Fundamental and Applied Sciences Solid dispersion baclofen sustained release adsorbent. |
| title | DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN |
| title_full | DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN |
| title_fullStr | DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN |
| title_full_unstemmed | DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN |
| title_short | DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN |
| title_sort | development of sustained release tablets containing solid dispersions of baclofen |
| topic | Solid dispersion baclofen sustained release adsorbent. |
| url | http://jfas.info/index.php/jfas/article/view/87 |
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