Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border
Dengue virus 2 (DENV-2) seriously contributes to dengue-related mortality. It includes five nonsylvatic genotypes, with cosmopolitan being the most widespread with a significant contribution to the total number of DENV-2 cases globally. In South America, the cosmopolitan genotype was first recorded...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/6/325 |
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| author | Murilo Tavares Amorim Leonardo H. Almeida Hernández Felipe Gomes Naveca Ivy Tsuya Essashika Prazeres Ana Lucia Monteiro Wanzeller Eliana Vieira Pinto da Silva Livia M. Neves Casseb Fábio Silva da Silva Sandro Patroca da Silva Bruno Tardelli Diniz Nunes Ana Cecília Ribeiro Cruz |
| author_facet | Murilo Tavares Amorim Leonardo H. Almeida Hernández Felipe Gomes Naveca Ivy Tsuya Essashika Prazeres Ana Lucia Monteiro Wanzeller Eliana Vieira Pinto da Silva Livia M. Neves Casseb Fábio Silva da Silva Sandro Patroca da Silva Bruno Tardelli Diniz Nunes Ana Cecília Ribeiro Cruz |
| author_sort | Murilo Tavares Amorim |
| collection | DOAJ |
| description | Dengue virus 2 (DENV-2) seriously contributes to dengue-related mortality. It includes five nonsylvatic genotypes, with cosmopolitan being the most widespread with a significant contribution to the total number of DENV-2 cases globally. In South America, the cosmopolitan genotype was first recorded in 2019 in Madre de Dios, Peru, and then in Goiás (Midwest Brazil) in November 2021. In this study, we tested 163 human serum samples from Acre (Northern Brazil) collected during a DENV outbreak between 2020 and 2021 for all DENV genotypes by RT-qPCR. Of the 163 samples, 139 were positive for DENV-2, and 5 were positive for DENV-1. Five DENV-2-positive samples from early 2021 were sequenced, and the sequences clustered with the three other DENV-2 cosmopolitan genotype sequences already recorded on the continent. These results create a geographical link, suggesting the possible route of introduction of the DENV-2 cosmopolitan genotype into Brazil through the border with Peru, from which it may have dispersed to Midwest Brazil. |
| first_indexed | 2024-03-11T01:50:54Z |
| format | Article |
| id | doaj.art-44f6521bbc394537b43d05de6fcc0511 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-11T01:50:54Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-44f6521bbc394537b43d05de6fcc05112023-11-18T12:56:35ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-06-018632510.3390/tropicalmed8060325Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian BorderMurilo Tavares Amorim0Leonardo H. Almeida Hernández1Felipe Gomes Naveca2Ivy Tsuya Essashika Prazeres3Ana Lucia Monteiro Wanzeller4Eliana Vieira Pinto da Silva5Livia M. Neves Casseb6Fábio Silva da Silva7Sandro Patroca da Silva8Bruno Tardelli Diniz Nunes9Ana Cecília Ribeiro Cruz10Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilDepartment of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health, Ananindeua 67030-000, BrazilOswaldo Cruz Foundation, Rio de Janeiro 21040-900, BrazilDepartment of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health, Ananindeua 67030-000, BrazilDepartment of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health, Ananindeua 67030-000, BrazilDepartment of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health, Ananindeua 67030-000, BrazilDepartment of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health, Ananindeua 67030-000, BrazilDepartment of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health, Ananindeua 67030-000, BrazilDepartment of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health, Ananindeua 67030-000, BrazilDepartment of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health, Ananindeua 67030-000, BrazilInstitute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilDengue virus 2 (DENV-2) seriously contributes to dengue-related mortality. It includes five nonsylvatic genotypes, with cosmopolitan being the most widespread with a significant contribution to the total number of DENV-2 cases globally. In South America, the cosmopolitan genotype was first recorded in 2019 in Madre de Dios, Peru, and then in Goiás (Midwest Brazil) in November 2021. In this study, we tested 163 human serum samples from Acre (Northern Brazil) collected during a DENV outbreak between 2020 and 2021 for all DENV genotypes by RT-qPCR. Of the 163 samples, 139 were positive for DENV-2, and 5 were positive for DENV-1. Five DENV-2-positive samples from early 2021 were sequenced, and the sequences clustered with the three other DENV-2 cosmopolitan genotype sequences already recorded on the continent. These results create a geographical link, suggesting the possible route of introduction of the DENV-2 cosmopolitan genotype into Brazil through the border with Peru, from which it may have dispersed to Midwest Brazil.https://www.mdpi.com/2414-6366/8/6/325arbovirusesdengue virus serotype 2cosmopolitan genotype |
| spellingShingle | Murilo Tavares Amorim Leonardo H. Almeida Hernández Felipe Gomes Naveca Ivy Tsuya Essashika Prazeres Ana Lucia Monteiro Wanzeller Eliana Vieira Pinto da Silva Livia M. Neves Casseb Fábio Silva da Silva Sandro Patroca da Silva Bruno Tardelli Diniz Nunes Ana Cecília Ribeiro Cruz Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border Tropical Medicine and Infectious Disease arboviruses dengue virus serotype 2 cosmopolitan genotype |
| title | Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border |
| title_full | Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border |
| title_fullStr | Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border |
| title_full_unstemmed | Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border |
| title_short | Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border |
| title_sort | emergence of a new strain of denv 2 in south america introduction of the cosmopolitan genotype through the brazilian peruvian border |
| topic | arboviruses dengue virus serotype 2 cosmopolitan genotype |
| url | https://www.mdpi.com/2414-6366/8/6/325 |
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