Acute toxic exposures in children: analysis of a three year registry managed by a Pediatric poison control Center in Italy
Abstract Introduction Acute pediatric poisoning is an emerging health and social problem. The aim of this study is to describe the characteristics of a large pediatric cohort exposed to xenobiotics, through the analysis of a Pediatric Poison Control Center (PPCc) registry. Methods This study, conduc...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-021-01071-y |
| _version_ | 1818441339653586944 |
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| author | M. Marano F. Rossi L. Ravà M. Khalil Ramla M. Pisani G. Bottari L. Genuini G. Zampini J. Nunziata A. Reale M. A. Barbieri F. Celeani M. Di Nardo C. Cecchetti F. Stoppa A. Villani M. Raponi S. Livadiotti G. Pontrelli |
| author_facet | M. Marano F. Rossi L. Ravà M. Khalil Ramla M. Pisani G. Bottari L. Genuini G. Zampini J. Nunziata A. Reale M. A. Barbieri F. Celeani M. Di Nardo C. Cecchetti F. Stoppa A. Villani M. Raponi S. Livadiotti G. Pontrelli |
| author_sort | M. Marano |
| collection | DOAJ |
| description | Abstract Introduction Acute pediatric poisoning is an emerging health and social problem. The aim of this study is to describe the characteristics of a large pediatric cohort exposed to xenobiotics, through the analysis of a Pediatric Poison Control Center (PPCc) registry. Methods This study, conducted in the Pediatric Hospital Bambino Gesù of Rome, a reference National Pediatric Hospital, collected data of children whose parents or caregivers contacted the PPCc by phone (group “P”), or who presented to the Emergency Department (group “ED”), during the three-year period 2014–2016. Data were prospectively and systematically collected in a pre-set electronic registry. Comparisons among age groups were performed and multivariable logistic regression models used to investigate associations with outcomes (hospital referral for “P”, and hospital admission for “ED”group). Results We collected data of 1611 children on group P and 1075 on group ED. Both groups were exposed to both pharmaceutical and non-pharmaceutical agents. Pharmaceutical agent exposure increased with age and the most common route of exposure was oral. Only 10% among P group were symptomatic children, with gastrointestinal symptoms. Among the ED patients, 30% were symptomatic children mostly with gastrointestinal (55.4%) and neurologic symptoms (23.8%). Intentional exposure (abuse substance and suicide attempt), which involved 7.7% of patients, was associated with older age and Hospital admission. Conclusions Our study describes the characteristics of xenobiotics exposures in different paediatric age groups, highlighting the impact of both pharmacological and intentional exposure. Furthermore, our study shows the utility of a specific PPCc, either through Phone support or by direct access to ED. PPCc phone counselling could avoid unnecessary access to the ED, a relevant achievement, particularly in the time of a pandemic. |
| first_indexed | 2024-12-14T18:26:41Z |
| format | Article |
| id | doaj.art-44f74fa991ba4512a3f849954b5a9012 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-12-14T18:26:41Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-44f74fa991ba4512a3f849954b5a90122022-12-21T22:51:54ZengBMCItalian Journal of Pediatrics1824-72882021-06-0147111310.1186/s13052-021-01071-yAcute toxic exposures in children: analysis of a three year registry managed by a Pediatric poison control Center in ItalyM. Marano0F. Rossi1L. Ravà2M. Khalil Ramla3M. Pisani4G. Bottari5L. Genuini6G. Zampini7J. Nunziata8A. Reale9M. A. Barbieri10F. Celeani11M. Di Nardo12C. Cecchetti13F. Stoppa14A. Villani15M. Raponi16S. Livadiotti17G. Pontrelli18DEA Paediatric Intensive Care Unit, Children’s Hospital Bambino Gesù, IRCCSEmergency Department, Children’s Hospital Bambino Gesù, IRCCSEpidemiology Unit and Biostatistics, Children’s Hospital Bambino Gesù, IRCCSPaediatric Clinical Toxicology Centre, Children’s Hospital Bambino Gesù, IRCCSEmergency Department, Children’s Hospital Bambino Gesù, IRCCSDEA Paediatric Intensive Care Unit, Children’s Hospital Bambino Gesù, IRCCSDEA Paediatric Intensive Care Unit, Children’s Hospital Bambino Gesù, IRCCSDEA Paediatric Intensive Care Unit, Children’s Hospital Bambino Gesù, IRCCSDEA Paediatric Intensive Care Unit, Children’s Hospital Bambino Gesù, IRCCSEmergency Department, Children’s Hospital Bambino Gesù, IRCCSEmergency Department, Children’s Hospital Bambino Gesù, IRCCSInformation Systems Department, General direction Children’s Hospital Bambino Gesù, IRCCSDEA Paediatric Intensive Care Unit, Children’s Hospital Bambino Gesù, IRCCSDEA Paediatric Intensive Care Unit, Children’s Hospital Bambino Gesù, IRCCSDEA Paediatric Intensive Care Unit, Children’s Hospital Bambino Gesù, IRCCSEmergency Department, Children’s Hospital Bambino Gesù, IRCCSMedical Direction, Children’s Hospital Bambino Gesù, IRCCSClinical Trials Centre, University Department of Paediatrics, Bambino Gesù Children’s Hospital, IRCCSClinical Trials Centre, University Department of Paediatrics, Bambino Gesù Children’s Hospital, IRCCSAbstract Introduction Acute pediatric poisoning is an emerging health and social problem. The aim of this study is to describe the characteristics of a large pediatric cohort exposed to xenobiotics, through the analysis of a Pediatric Poison Control Center (PPCc) registry. Methods This study, conducted in the Pediatric Hospital Bambino Gesù of Rome, a reference National Pediatric Hospital, collected data of children whose parents or caregivers contacted the PPCc by phone (group “P”), or who presented to the Emergency Department (group “ED”), during the three-year period 2014–2016. Data were prospectively and systematically collected in a pre-set electronic registry. Comparisons among age groups were performed and multivariable logistic regression models used to investigate associations with outcomes (hospital referral for “P”, and hospital admission for “ED”group). Results We collected data of 1611 children on group P and 1075 on group ED. Both groups were exposed to both pharmaceutical and non-pharmaceutical agents. Pharmaceutical agent exposure increased with age and the most common route of exposure was oral. Only 10% among P group were symptomatic children, with gastrointestinal symptoms. Among the ED patients, 30% were symptomatic children mostly with gastrointestinal (55.4%) and neurologic symptoms (23.8%). Intentional exposure (abuse substance and suicide attempt), which involved 7.7% of patients, was associated with older age and Hospital admission. Conclusions Our study describes the characteristics of xenobiotics exposures in different paediatric age groups, highlighting the impact of both pharmacological and intentional exposure. Furthermore, our study shows the utility of a specific PPCc, either through Phone support or by direct access to ED. PPCc phone counselling could avoid unnecessary access to the ED, a relevant achievement, particularly in the time of a pandemic.https://doi.org/10.1186/s13052-021-01071-yPaediatric poisoningIntoxicationPharmaceuticalsEmergency departmentChildhoodPoison control Centre |
| spellingShingle | M. Marano F. Rossi L. Ravà M. Khalil Ramla M. Pisani G. Bottari L. Genuini G. Zampini J. Nunziata A. Reale M. A. Barbieri F. Celeani M. Di Nardo C. Cecchetti F. Stoppa A. Villani M. Raponi S. Livadiotti G. Pontrelli Acute toxic exposures in children: analysis of a three year registry managed by a Pediatric poison control Center in Italy Italian Journal of Pediatrics Paediatric poisoning Intoxication Pharmaceuticals Emergency department Childhood Poison control Centre |
| title | Acute toxic exposures in children: analysis of a three year registry managed by a Pediatric poison control Center in Italy |
| title_full | Acute toxic exposures in children: analysis of a three year registry managed by a Pediatric poison control Center in Italy |
| title_fullStr | Acute toxic exposures in children: analysis of a three year registry managed by a Pediatric poison control Center in Italy |
| title_full_unstemmed | Acute toxic exposures in children: analysis of a three year registry managed by a Pediatric poison control Center in Italy |
| title_short | Acute toxic exposures in children: analysis of a three year registry managed by a Pediatric poison control Center in Italy |
| title_sort | acute toxic exposures in children analysis of a three year registry managed by a pediatric poison control center in italy |
| topic | Paediatric poisoning Intoxication Pharmaceuticals Emergency department Childhood Poison control Centre |
| url | https://doi.org/10.1186/s13052-021-01071-y |
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