Case report: Coexistence of sigmoid tumor with unusual pathological features and multiple colorectal neuroendocrine tumors with lymph node metastases
The coexistence of adenocarcinoma and neuroendocrine neoplasm (NEN) in the same tumor is rare. What is rarer is that the neuroendocrine component is a well-differentiated neuroendocrine tumor (NET) Grade (G) 1. Most colorectal NETs are single, but multiple neuroendocrine tumors (M-NETs) are rare. We...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1073234/full |
| _version_ | 1827992541174169600 |
|---|---|
| author | Shu Pang Jiugang Song Kun Zhang Jia Wang Haiying Zhao Yongjun Wang Peng Li Ye Zong Yongdong Wu |
| author_facet | Shu Pang Jiugang Song Kun Zhang Jia Wang Haiying Zhao Yongjun Wang Peng Li Ye Zong Yongdong Wu |
| author_sort | Shu Pang |
| collection | DOAJ |
| description | The coexistence of adenocarcinoma and neuroendocrine neoplasm (NEN) in the same tumor is rare. What is rarer is that the neuroendocrine component is a well-differentiated neuroendocrine tumor (NET) Grade (G) 1. Most colorectal NETs are single, but multiple neuroendocrine tumors (M-NETs) are rare. Well-differentiated NETs rarely metastasize. Here, we present a unique case of a synchronous sigmoid tumor and multiple colorectal NETs with lymph node metastases. The sigmoid tumor consisted of adenocarcinoma and NET G1. The metastatic component was NET G1. A 64-year-old man underwent a colonoscopy for persistent changes in bowel habits and positive fecal occult blood for 1 year. An ulcerative lesion, which was diagnosed as colon cancer, was seen in the sigmoid colon. In addition, scattered lesions could be seen in the colon and rectum. Surgical resection was performed. Pathological findings suggested that the ulcerative lesion was composed of 80% adenocarcinoma and 20% neuroendocrine component (NET G1), while the remaining lesions were consistent with NET G1. At the same time, 11 lymph nodes around the resected intestinal segment were invaded by NET G1. The prognosis of the patient was good. After 13 months of follow-up, no recurrence and no metastasis were found. We hope to provide a reference and improve our understanding of the clinicopathological features and biological behavior of these unique tumors. We also aim to emphasize the importance of radical surgery and individualized treatment. |
| first_indexed | 2024-04-10T04:07:02Z |
| format | Article |
| id | doaj.art-44f978b9d22f483fbfe4060bf7194dc4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T04:07:02Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-44f978b9d22f483fbfe4060bf7194dc42023-03-13T04:52:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.10732341073234Case report: Coexistence of sigmoid tumor with unusual pathological features and multiple colorectal neuroendocrine tumors with lymph node metastasesShu Pang0Jiugang Song1Kun Zhang2Jia Wang3Haiying Zhao4Yongjun Wang5Peng Li6Ye Zong7Yongdong Wu8Department of General Practice, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Ultrasonography, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaThe coexistence of adenocarcinoma and neuroendocrine neoplasm (NEN) in the same tumor is rare. What is rarer is that the neuroendocrine component is a well-differentiated neuroendocrine tumor (NET) Grade (G) 1. Most colorectal NETs are single, but multiple neuroendocrine tumors (M-NETs) are rare. Well-differentiated NETs rarely metastasize. Here, we present a unique case of a synchronous sigmoid tumor and multiple colorectal NETs with lymph node metastases. The sigmoid tumor consisted of adenocarcinoma and NET G1. The metastatic component was NET G1. A 64-year-old man underwent a colonoscopy for persistent changes in bowel habits and positive fecal occult blood for 1 year. An ulcerative lesion, which was diagnosed as colon cancer, was seen in the sigmoid colon. In addition, scattered lesions could be seen in the colon and rectum. Surgical resection was performed. Pathological findings suggested that the ulcerative lesion was composed of 80% adenocarcinoma and 20% neuroendocrine component (NET G1), while the remaining lesions were consistent with NET G1. At the same time, 11 lymph nodes around the resected intestinal segment were invaded by NET G1. The prognosis of the patient was good. After 13 months of follow-up, no recurrence and no metastasis were found. We hope to provide a reference and improve our understanding of the clinicopathological features and biological behavior of these unique tumors. We also aim to emphasize the importance of radical surgery and individualized treatment.https://www.frontiersin.org/articles/10.3389/fonc.2023.1073234/fullsigmoid neoplasmmultiple colorectal neuroendocrine tumorslymph nodes metastasesneuroendocrineadenocarcinomacase report |
| spellingShingle | Shu Pang Jiugang Song Kun Zhang Jia Wang Haiying Zhao Yongjun Wang Peng Li Ye Zong Yongdong Wu Case report: Coexistence of sigmoid tumor with unusual pathological features and multiple colorectal neuroendocrine tumors with lymph node metastases Frontiers in Oncology sigmoid neoplasm multiple colorectal neuroendocrine tumors lymph nodes metastases neuroendocrine adenocarcinoma case report |
| title | Case report: Coexistence of sigmoid tumor with unusual pathological features and multiple colorectal neuroendocrine tumors with lymph node metastases |
| title_full | Case report: Coexistence of sigmoid tumor with unusual pathological features and multiple colorectal neuroendocrine tumors with lymph node metastases |
| title_fullStr | Case report: Coexistence of sigmoid tumor with unusual pathological features and multiple colorectal neuroendocrine tumors with lymph node metastases |
| title_full_unstemmed | Case report: Coexistence of sigmoid tumor with unusual pathological features and multiple colorectal neuroendocrine tumors with lymph node metastases |
| title_short | Case report: Coexistence of sigmoid tumor with unusual pathological features and multiple colorectal neuroendocrine tumors with lymph node metastases |
| title_sort | case report coexistence of sigmoid tumor with unusual pathological features and multiple colorectal neuroendocrine tumors with lymph node metastases |
| topic | sigmoid neoplasm multiple colorectal neuroendocrine tumors lymph nodes metastases neuroendocrine adenocarcinoma case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1073234/full |
| work_keys_str_mv | AT shupang casereportcoexistenceofsigmoidtumorwithunusualpathologicalfeaturesandmultiplecolorectalneuroendocrinetumorswithlymphnodemetastases AT jiugangsong casereportcoexistenceofsigmoidtumorwithunusualpathologicalfeaturesandmultiplecolorectalneuroendocrinetumorswithlymphnodemetastases AT kunzhang casereportcoexistenceofsigmoidtumorwithunusualpathologicalfeaturesandmultiplecolorectalneuroendocrinetumorswithlymphnodemetastases AT jiawang casereportcoexistenceofsigmoidtumorwithunusualpathologicalfeaturesandmultiplecolorectalneuroendocrinetumorswithlymphnodemetastases AT haiyingzhao casereportcoexistenceofsigmoidtumorwithunusualpathologicalfeaturesandmultiplecolorectalneuroendocrinetumorswithlymphnodemetastases AT yongjunwang casereportcoexistenceofsigmoidtumorwithunusualpathologicalfeaturesandmultiplecolorectalneuroendocrinetumorswithlymphnodemetastases AT pengli casereportcoexistenceofsigmoidtumorwithunusualpathologicalfeaturesandmultiplecolorectalneuroendocrinetumorswithlymphnodemetastases AT yezong casereportcoexistenceofsigmoidtumorwithunusualpathologicalfeaturesandmultiplecolorectalneuroendocrinetumorswithlymphnodemetastases AT yongdongwu casereportcoexistenceofsigmoidtumorwithunusualpathologicalfeaturesandmultiplecolorectalneuroendocrinetumorswithlymphnodemetastases |