Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder
MCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, the effects on the circadian rhythm and thyroid in adult mice have not been studied. In this article, adult male mice received MCA at concentrations of 0, 10, 20, 30 mg/kg. The results...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651321011040 |
| _version_ | 1818700789146714112 |
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| author | Sijie Wang Songdi Wang Chenxi Wang Daofu Feng Xizeng Feng |
| author_facet | Sijie Wang Songdi Wang Chenxi Wang Daofu Feng Xizeng Feng |
| author_sort | Sijie Wang |
| collection | DOAJ |
| description | MCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, the effects on the circadian rhythm and thyroid in adult mice have not been studied. In this article, adult male mice received MCA at concentrations of 0, 10, 20, 30 mg/kg. The results showed that the time spending on wheel-running and rest bouts changed in different period after MCA exposure. MCA disrupted the T3 and T4 hormone homeostasis and decreased the expression of thyroid hormone synthesis genes. The histological morphology of the thyroid gland was damaged. It was suggested that MCA exposure caused circadian rhythm disorder and thyroid dysfunction. |
| first_indexed | 2024-12-17T15:10:31Z |
| format | Article |
| id | doaj.art-44f9c4c96cb4456ea1550f9011a93257 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-17T15:10:31Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-44f9c4c96cb4456ea1550f9011a932572022-12-21T21:43:40ZengElsevierEcotoxicology and Environmental Safety0147-65132021-12-01228112992Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorderSijie Wang0Songdi Wang1Chenxi Wang2Daofu Feng3Xizeng Feng4The Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Science, Nankai University, Tianjin 300071, ChinaThe Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Science, Nankai University, Tianjin 300071, ChinaThe Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Science, Nankai University, Tianjin 300071, ChinaDepartment of General Surgery, Tianjin Medical University General Hospital, No. 154 Anshan Road, Tianjin 300052, China; Corresponding authors.The Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Science, Nankai University, Tianjin 300071, China; Corresponding authors.MCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, the effects on the circadian rhythm and thyroid in adult mice have not been studied. In this article, adult male mice received MCA at concentrations of 0, 10, 20, 30 mg/kg. The results showed that the time spending on wheel-running and rest bouts changed in different period after MCA exposure. MCA disrupted the T3 and T4 hormone homeostasis and decreased the expression of thyroid hormone synthesis genes. The histological morphology of the thyroid gland was damaged. It was suggested that MCA exposure caused circadian rhythm disorder and thyroid dysfunction.http://www.sciencedirect.com/science/article/pii/S0147651321011040Melamine cyanuric acidThyroidCircadian rhythmUCP1 |
| spellingShingle | Sijie Wang Songdi Wang Chenxi Wang Daofu Feng Xizeng Feng Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder Ecotoxicology and Environmental Safety Melamine cyanuric acid Thyroid Circadian rhythm UCP1 |
| title | Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder |
| title_full | Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder |
| title_fullStr | Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder |
| title_full_unstemmed | Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder |
| title_short | Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder |
| title_sort | exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder |
| topic | Melamine cyanuric acid Thyroid Circadian rhythm UCP1 |
| url | http://www.sciencedirect.com/science/article/pii/S0147651321011040 |
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