Stenotrophomonas maltophilia neonatal sepsis: a case report
Abstract Background Stenotrophomonas maltophilia is a gram-negative bacteria known for causing opportunistic and nosocomial infections in humans. S. maltophilia is an emerging pathogen of concern due to it’s increasing prevalence, diverse disease spectrum, intrinsic multi-drug resistance and high mo...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-024-04479-2 |
| _version_ | 1797233517362413568 |
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| author | Williams Oluwatosin Adefila Isaac Osie Modou Lamin Keita Baleng Mahama Wutor Abdulsalam Olawale Yusuf Ilias Hossain Minteh Molfa Ousman Barjo Rasheed Salaudeen Grant Mackenzie |
| author_facet | Williams Oluwatosin Adefila Isaac Osie Modou Lamin Keita Baleng Mahama Wutor Abdulsalam Olawale Yusuf Ilias Hossain Minteh Molfa Ousman Barjo Rasheed Salaudeen Grant Mackenzie |
| author_sort | Williams Oluwatosin Adefila |
| collection | DOAJ |
| description | Abstract Background Stenotrophomonas maltophilia is a gram-negative bacteria known for causing opportunistic and nosocomial infections in humans. S. maltophilia is an emerging pathogen of concern due to it’s increasing prevalence, diverse disease spectrum, intrinsic multi-drug resistance and high mortality rates in immunocompromised individuals. S. maltophilia is a rare cause of neonatal sepsis associated with significant morbidity and mortality. The bacterium’s multi-drug resistance poses a considerable challenge for treatment, with various mechanisms contributing to its resistance. Case presentation We report a case involving a 40-h-old male African neonate who exhibited symptoms of neonatal sepsis. The blood culture revealed Stenotrophomonas maltophilia, which was sensitive to ciprofloxacin and gentamicin but resistant to other antibiotics. Lumbar puncture for CSF could not be done because the father declined. We treated the newborn with the empirical first-line antibiotics as per the national guideline intravenous ampicillin and gentamicin for six days, and the child recovered fully with a repeated negative blood culture. Conclusions This report describes a neonatal sepsis case caused by S. maltophilia, a multi-drug resistant bacteria and a rare cause of neonatal sepsis. We report that early detection of the bacterial and antimicrobial management based on local antibiogram data may be essential for successful patient’s management. |
| first_indexed | 2024-04-24T16:17:26Z |
| format | Article |
| id | doaj.art-44faab60761540808d8bb9921898bbe4 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-24T16:17:26Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-44faab60761540808d8bb9921898bbe42024-03-31T11:21:59ZengBMCJournal of Medical Case Reports1752-19472024-03-011811510.1186/s13256-024-04479-2Stenotrophomonas maltophilia neonatal sepsis: a case reportWilliams Oluwatosin Adefila0Isaac Osie1Modou Lamin Keita2Baleng Mahama Wutor3Abdulsalam Olawale Yusuf4Ilias Hossain5Minteh Molfa6Ousman Barjo7Rasheed Salaudeen8Grant Mackenzie9Medical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London, School of Hygiene and Tropical MedicineAbstract Background Stenotrophomonas maltophilia is a gram-negative bacteria known for causing opportunistic and nosocomial infections in humans. S. maltophilia is an emerging pathogen of concern due to it’s increasing prevalence, diverse disease spectrum, intrinsic multi-drug resistance and high mortality rates in immunocompromised individuals. S. maltophilia is a rare cause of neonatal sepsis associated with significant morbidity and mortality. The bacterium’s multi-drug resistance poses a considerable challenge for treatment, with various mechanisms contributing to its resistance. Case presentation We report a case involving a 40-h-old male African neonate who exhibited symptoms of neonatal sepsis. The blood culture revealed Stenotrophomonas maltophilia, which was sensitive to ciprofloxacin and gentamicin but resistant to other antibiotics. Lumbar puncture for CSF could not be done because the father declined. We treated the newborn with the empirical first-line antibiotics as per the national guideline intravenous ampicillin and gentamicin for six days, and the child recovered fully with a repeated negative blood culture. Conclusions This report describes a neonatal sepsis case caused by S. maltophilia, a multi-drug resistant bacteria and a rare cause of neonatal sepsis. We report that early detection of the bacterial and antimicrobial management based on local antibiogram data may be essential for successful patient’s management.https://doi.org/10.1186/s13256-024-04479-2Case reportNeonatal sepsisStenotrophomonas maltophiliaAntibiotic treatmentMultidrug-resistant |
| spellingShingle | Williams Oluwatosin Adefila Isaac Osie Modou Lamin Keita Baleng Mahama Wutor Abdulsalam Olawale Yusuf Ilias Hossain Minteh Molfa Ousman Barjo Rasheed Salaudeen Grant Mackenzie Stenotrophomonas maltophilia neonatal sepsis: a case report Journal of Medical Case Reports Case report Neonatal sepsis Stenotrophomonas maltophilia Antibiotic treatment Multidrug-resistant |
| title | Stenotrophomonas maltophilia neonatal sepsis: a case report |
| title_full | Stenotrophomonas maltophilia neonatal sepsis: a case report |
| title_fullStr | Stenotrophomonas maltophilia neonatal sepsis: a case report |
| title_full_unstemmed | Stenotrophomonas maltophilia neonatal sepsis: a case report |
| title_short | Stenotrophomonas maltophilia neonatal sepsis: a case report |
| title_sort | stenotrophomonas maltophilia neonatal sepsis a case report |
| topic | Case report Neonatal sepsis Stenotrophomonas maltophilia Antibiotic treatment Multidrug-resistant |
| url | https://doi.org/10.1186/s13256-024-04479-2 |
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