| Summary: | Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is an alternative to surgery for acute cholecystitis (AC) in poor operative candidates. However, the role of EUS-GBD in non-cholecystitis (NC) indications has not been well studied. We compared the clinical outcomes of EUS-GBD for AC and NC indications. Consecutive patients undergoing EUS-GBD for all indications at a single center were retrospectively analyzed. Fifty-one patients underwent EUS-GBD during the study period. Thirty-nine (76%) patients had AC while 12 (24%) had NC indications. NC indications included malignant biliary obstruction (<i>n</i> = 8), symptomatic cholelithiasis (<i>n</i> = 1), gallstone pancreatitis (<i>n</i> = 1), choledocholithiasis (<i>n</i> = 1), and Mirizzi’s syndrome (<i>n</i> = 1). Technical success was noted in 92% (36/39) for AC and 92% (11/12) for NC (<i>p</i> > 0.99). The clinical success rate was 94% and 100%, respectively (<i>p</i> > 0.99). There were four adverse events in the AC group and 3 in the NC group (<i>p</i> = 0.33). Procedure duration (median 43 vs. 45 min, <i>p</i> = 0.37), post-procedure length of stay (median 3 vs. 3 days, <i>p</i> = 0.97), and total gallbladder-related procedures (median 2 vs. 2, <i>p</i> = 0.59) were similar. EUS-GBD for NC indications is similarly safe and effective as EUS-GBD in AC.
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