Influence of polyphenols from olive mill wastewater on the gastrointestinal tract, alveolar macrophages and blood leukocytes of pigs
In the last years, great importance has been given to the beneficial effects of polyphenols. Among the most relevant health promoting effects, there is the capacity to reduce the amount of free radicals and stimulate the immune response. In this study, polyphenols extracted from olive mill wastewate...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
|
| Series: | Italian Journal of Animal Science |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/1828051X.2018.1548911 |
| _version_ | 1818858864849715200 |
|---|---|
| author | Ettore Varricchio Elena Coccia Graziella Orso Vittoria Lombardi Roberta Imperatore Pasquale Vito Marina Paolucci |
| author_facet | Ettore Varricchio Elena Coccia Graziella Orso Vittoria Lombardi Roberta Imperatore Pasquale Vito Marina Paolucci |
| author_sort | Ettore Varricchio |
| collection | DOAJ |
| description | In the last years, great importance has been given to the beneficial effects of polyphenols. Among the most relevant health promoting effects, there is the capacity to reduce the amount of free radicals and stimulate the immune response. In this study, polyphenols extracted from olive mill wastewater (OMWW), were fed to adult ‘Casertana’ pigs during the finishing period. No significant differences in the length of the jejunum-ileum villi and the depth of the colon crypts were detected between control and polyphenols fed pigs. Instead, intra-epithelial and lamina propria leukocytes were more abundant in pigs fed polyphenols (p < .05). Cyclooxygenase-2 immunoreactivity in the gastrointestinal tract, employed as marker of inflammation, was more intense in the control group. Superoxide anion production in primary cell cultures of both blood leukocytes and alveolar macrophages was lower in pigs fed polyphenols (p < .05). Taken together these data indicate that, according to our in vitro studies, OMWW polyphenols seem to be potent antioxidants, while the interpretation of the in vivo experiments is more problematic and further studies are necessary on the interactions between bioactive feed compounds and intestinal status. Such studies can contribute to a better understanding of both positive and negative interactions in vivo and to the identification of new functional feeds.HIGHLIGHTS The effects of polyphenols extracted from olive mill wastewater (OMWW) have been studied in pigs. Gut morphology, inflammation and immune response were investigated. OMWW polyphenols act as potent antioxidants. |
| first_indexed | 2024-12-19T09:03:04Z |
| format | Article |
| id | doaj.art-44fb47d184604e6096bea69a3ffac447 |
| institution | Directory Open Access Journal |
| issn | 1828-051X |
| language | English |
| last_indexed | 2024-12-19T09:03:04Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj.art-44fb47d184604e6096bea69a3ffac4472022-12-21T20:28:25ZengTaylor & Francis GroupItalian Journal of Animal Science1828-051X2019-01-0118157458610.1080/1828051X.2018.15489111548911Influence of polyphenols from olive mill wastewater on the gastrointestinal tract, alveolar macrophages and blood leukocytes of pigsEttore Varricchio0Elena Coccia1Graziella Orso2Vittoria Lombardi3Roberta Imperatore4Pasquale Vito5Marina Paolucci6University of SannioUniversity of SannioUniversity of SannioUniversity of SannioUniversity of SannioUniversity of SannioUniversity of SannioIn the last years, great importance has been given to the beneficial effects of polyphenols. Among the most relevant health promoting effects, there is the capacity to reduce the amount of free radicals and stimulate the immune response. In this study, polyphenols extracted from olive mill wastewater (OMWW), were fed to adult ‘Casertana’ pigs during the finishing period. No significant differences in the length of the jejunum-ileum villi and the depth of the colon crypts were detected between control and polyphenols fed pigs. Instead, intra-epithelial and lamina propria leukocytes were more abundant in pigs fed polyphenols (p < .05). Cyclooxygenase-2 immunoreactivity in the gastrointestinal tract, employed as marker of inflammation, was more intense in the control group. Superoxide anion production in primary cell cultures of both blood leukocytes and alveolar macrophages was lower in pigs fed polyphenols (p < .05). Taken together these data indicate that, according to our in vitro studies, OMWW polyphenols seem to be potent antioxidants, while the interpretation of the in vivo experiments is more problematic and further studies are necessary on the interactions between bioactive feed compounds and intestinal status. Such studies can contribute to a better understanding of both positive and negative interactions in vivo and to the identification of new functional feeds.HIGHLIGHTS The effects of polyphenols extracted from olive mill wastewater (OMWW) have been studied in pigs. Gut morphology, inflammation and immune response were investigated. OMWW polyphenols act as potent antioxidants.http://dx.doi.org/10.1080/1828051X.2018.1548911casertana strain pigspolyphenolsintestinal histologycox-2 expressionsuperoxide anion |
| spellingShingle | Ettore Varricchio Elena Coccia Graziella Orso Vittoria Lombardi Roberta Imperatore Pasquale Vito Marina Paolucci Influence of polyphenols from olive mill wastewater on the gastrointestinal tract, alveolar macrophages and blood leukocytes of pigs Italian Journal of Animal Science casertana strain pigs polyphenols intestinal histology cox-2 expression superoxide anion |
| title | Influence of polyphenols from olive mill wastewater on the gastrointestinal tract, alveolar macrophages and blood leukocytes of pigs |
| title_full | Influence of polyphenols from olive mill wastewater on the gastrointestinal tract, alveolar macrophages and blood leukocytes of pigs |
| title_fullStr | Influence of polyphenols from olive mill wastewater on the gastrointestinal tract, alveolar macrophages and blood leukocytes of pigs |
| title_full_unstemmed | Influence of polyphenols from olive mill wastewater on the gastrointestinal tract, alveolar macrophages and blood leukocytes of pigs |
| title_short | Influence of polyphenols from olive mill wastewater on the gastrointestinal tract, alveolar macrophages and blood leukocytes of pigs |
| title_sort | influence of polyphenols from olive mill wastewater on the gastrointestinal tract alveolar macrophages and blood leukocytes of pigs |
| topic | casertana strain pigs polyphenols intestinal histology cox-2 expression superoxide anion |
| url | http://dx.doi.org/10.1080/1828051X.2018.1548911 |
| work_keys_str_mv | AT ettorevarricchio influenceofpolyphenolsfromolivemillwastewateronthegastrointestinaltractalveolarmacrophagesandbloodleukocytesofpigs AT elenacoccia influenceofpolyphenolsfromolivemillwastewateronthegastrointestinaltractalveolarmacrophagesandbloodleukocytesofpigs AT graziellaorso influenceofpolyphenolsfromolivemillwastewateronthegastrointestinaltractalveolarmacrophagesandbloodleukocytesofpigs AT vittorialombardi influenceofpolyphenolsfromolivemillwastewateronthegastrointestinaltractalveolarmacrophagesandbloodleukocytesofpigs AT robertaimperatore influenceofpolyphenolsfromolivemillwastewateronthegastrointestinaltractalveolarmacrophagesandbloodleukocytesofpigs AT pasqualevito influenceofpolyphenolsfromolivemillwastewateronthegastrointestinaltractalveolarmacrophagesandbloodleukocytesofpigs AT marinapaolucci influenceofpolyphenolsfromolivemillwastewateronthegastrointestinaltractalveolarmacrophagesandbloodleukocytesofpigs |