SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.

SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.

Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state. The restricted and reciprocal expression of the collagen X gene, Col10a1, in hypertrophic chondrocytes and Sox9 in immature cho...

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Bibliographic Details
Main Authors: Victor Y L Leung, Bo Gao, Keith K H Leung, Ian G Melhado, Sarah L Wynn, Tiffany Y K Au, Nelson W F Dung, James Y B Lau, Angel C Y Mak, Danny Chan, Kathryn S E Cheah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3207907?pdf=render

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