A 15-Year Retrospective Survey of the Cytopathologic Spectrum of Cerebrospinal Fluid Aspirate in a Teaching Hospital in Uyo, Southern Nigeria
Background: The cytopathologic evaluation of cerebrospinal fluid (CSF) aspirates is a vital diagnostic tool for neurological disorders. This research aimed to characterize the diverse range of cytopathological diagnoses encountered in the CSF specimens within 15 years in a teaching hospital while h...
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| Format: | Article |
| Language: | English |
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Nigerian Medical Association, Akwa Ibom State Branch
2024-01-01
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| Series: | Ibom Medical Journal |
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| Online Access: | https://ibommedicaljournal.org/index.php/imjhome/article/view/369 |
| _version_ | 1797271933869359104 |
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| author | Eziagu UB Wemimo RM Nwafor CC Kudamnya IJ Ndukwe CO Okwudili NW Eziagu ED Chibuike IO Oyewumi AO |
| author_facet | Eziagu UB Wemimo RM Nwafor CC Kudamnya IJ Ndukwe CO Okwudili NW Eziagu ED Chibuike IO Oyewumi AO |
| author_sort | Eziagu UB |
| collection | DOAJ |
| description |
Background: The cytopathologic evaluation of cerebrospinal fluid (CSF) aspirates is a vital diagnostic tool for neurological disorders. This research aimed to characterize the diverse range of cytopathological diagnoses encountered in the CSF specimens within 15 years in a teaching hospital while highlighting their clinical significance.
Materials and Methods: A thorough review of cytopathology records from January 1, 2006, to December 31, 2020, was conducted. CSF samples were collected through lumbar punctures and subsequently subjected to cytopathological examination. The data were collected from the Department of Histopathology, University of Uyo Teaching Hospital archives. The inclusion criteria encompassed all cases with available CSF cytopathology results during the study period. Cases with inadequate or missing data were excluded from the analysis. Data regarding patients’ ages, sex, clinical, and cytopathologic diagnoses were extracted and analyzed.
Results: Thirty-four (34) CSF samples were analyzed during the study period. The mean age was 11.45 ± 12.20 years. The most common clinical indication for CSF analysis was suspected Burkitt’s Lymphoma (34.78%), followed by other Non-Hodgkin Lymphoma (13.04%). The cytopathologic diagnoses exhibited a diverse spectrum, including Acellular Smear (26.5%), Inflammatory Smear (2.9%), Negative for Malignant Cells (52.9%), Positive for Malignant Cells (14.7%), and Suspicious for Malignant Cells (2.9%). This study also observed a significant association between age groups (particularly 0-10 years) and cytopathological diagnoses, with a p-value of 0.023.
Conclusion: A retrospective survey of CSF cytopathology in a Nigerian teaching hospital reveals diverse cytopathological diagnoses, providing insights for neuropathology clinicians and researchers.
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| first_indexed | 2024-03-07T14:16:23Z |
| format | Article |
| id | doaj.art-44fd8a26548441378971a6b48d919679 |
| institution | Directory Open Access Journal |
| issn | 1597-7188 2735-9964 |
| language | English |
| last_indexed | 2024-03-07T14:16:23Z |
| publishDate | 2024-01-01 |
| publisher | Nigerian Medical Association, Akwa Ibom State Branch |
| record_format | Article |
| series | Ibom Medical Journal |
| spelling | doaj.art-44fd8a26548441378971a6b48d9196792024-03-06T11:55:07ZengNigerian Medical Association, Akwa Ibom State BranchIbom Medical Journal1597-71882735-99642024-01-0117110.61386/imj.v17i1.369A 15-Year Retrospective Survey of the Cytopathologic Spectrum of Cerebrospinal Fluid Aspirate in a Teaching Hospital in Uyo, Southern NigeriaEziagu UB0Wemimo RM1Nwafor CC2Kudamnya IJ3Ndukwe CO4Okwudili NW5Eziagu ED6Chibuike IO7Oyewumi AO8Department of Histopathology, University of Uyo Teaching Hospital, P.M.B. 1136, Uyo, Akwa Ibom State, NigeriaDepartment of Anatomic Pathology, Federal University Dutse (FUD), Dutse, Jigawa State, NigeriaDepartment of Histopathology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, NigeriaDepartment of Histopathology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, NigeriaDepartment of Anatomic Pathology and Forensic Medicine, Nnamdi Azikiwe University, Awka/Nnewi, Anambra State, NigeriaDepartment of Histopathology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, NigeriaLiving Word Missions Hospital, Aba, Abia State, NigeriaDepartment of Histopathology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, NigeriaDepartment of Histopathology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria Background: The cytopathologic evaluation of cerebrospinal fluid (CSF) aspirates is a vital diagnostic tool for neurological disorders. This research aimed to characterize the diverse range of cytopathological diagnoses encountered in the CSF specimens within 15 years in a teaching hospital while highlighting their clinical significance. Materials and Methods: A thorough review of cytopathology records from January 1, 2006, to December 31, 2020, was conducted. CSF samples were collected through lumbar punctures and subsequently subjected to cytopathological examination. The data were collected from the Department of Histopathology, University of Uyo Teaching Hospital archives. The inclusion criteria encompassed all cases with available CSF cytopathology results during the study period. Cases with inadequate or missing data were excluded from the analysis. Data regarding patients’ ages, sex, clinical, and cytopathologic diagnoses were extracted and analyzed. Results: Thirty-four (34) CSF samples were analyzed during the study period. The mean age was 11.45 ± 12.20 years. The most common clinical indication for CSF analysis was suspected Burkitt’s Lymphoma (34.78%), followed by other Non-Hodgkin Lymphoma (13.04%). The cytopathologic diagnoses exhibited a diverse spectrum, including Acellular Smear (26.5%), Inflammatory Smear (2.9%), Negative for Malignant Cells (52.9%), Positive for Malignant Cells (14.7%), and Suspicious for Malignant Cells (2.9%). This study also observed a significant association between age groups (particularly 0-10 years) and cytopathological diagnoses, with a p-value of 0.023. Conclusion: A retrospective survey of CSF cytopathology in a Nigerian teaching hospital reveals diverse cytopathological diagnoses, providing insights for neuropathology clinicians and researchers. https://ibommedicaljournal.org/index.php/imjhome/article/view/369Cerebrospinal Fluid (CSF)AspirateCytopathologyRetrospective StudySpectrumUyo |
| spellingShingle | Eziagu UB Wemimo RM Nwafor CC Kudamnya IJ Ndukwe CO Okwudili NW Eziagu ED Chibuike IO Oyewumi AO A 15-Year Retrospective Survey of the Cytopathologic Spectrum of Cerebrospinal Fluid Aspirate in a Teaching Hospital in Uyo, Southern Nigeria Ibom Medical Journal Cerebrospinal Fluid (CSF) Aspirate Cytopathology Retrospective Study Spectrum Uyo |
| title | A 15-Year Retrospective Survey of the Cytopathologic Spectrum of Cerebrospinal Fluid Aspirate in a Teaching Hospital in Uyo, Southern Nigeria |
| title_full | A 15-Year Retrospective Survey of the Cytopathologic Spectrum of Cerebrospinal Fluid Aspirate in a Teaching Hospital in Uyo, Southern Nigeria |
| title_fullStr | A 15-Year Retrospective Survey of the Cytopathologic Spectrum of Cerebrospinal Fluid Aspirate in a Teaching Hospital in Uyo, Southern Nigeria |
| title_full_unstemmed | A 15-Year Retrospective Survey of the Cytopathologic Spectrum of Cerebrospinal Fluid Aspirate in a Teaching Hospital in Uyo, Southern Nigeria |
| title_short | A 15-Year Retrospective Survey of the Cytopathologic Spectrum of Cerebrospinal Fluid Aspirate in a Teaching Hospital in Uyo, Southern Nigeria |
| title_sort | 15 year retrospective survey of the cytopathologic spectrum of cerebrospinal fluid aspirate in a teaching hospital in uyo southern nigeria |
| topic | Cerebrospinal Fluid (CSF) Aspirate Cytopathology Retrospective Study Spectrum Uyo |
| url | https://ibommedicaljournal.org/index.php/imjhome/article/view/369 |
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