Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma
Vascular endothelial growth factors receptors (VEGFR) inhibitors play a vital role in the treatment of renal cell carcinoma. These are small molecules that predominantly exhibit anti-angiogenesis activity in conjunction with other anti-tumor effects. These drug therapies are approved for the use in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universitas Ahmad Dahlan
2023-07-01
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| Series: | Pharmaciana |
| Subjects: | |
| Online Access: | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/24638/pdf_283 |
| _version_ | 1797739748206313472 |
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| author | Jie Yi Tan Aadya Jaipuria Ronny Priefer |
| author_facet | Jie Yi Tan Aadya Jaipuria Ronny Priefer |
| author_sort | Jie Yi Tan |
| collection | DOAJ |
| description | Vascular endothelial growth factors receptors (VEGFR) inhibitors play a vital role in the treatment of renal cell carcinoma. These are small molecules that predominantly exhibit anti-angiogenesis activity in conjunction with other anti-tumor effects. These drug therapies are approved for the use in patients as frontline agents or adjuvant therapy in renal cell carcinoma. However, VEGFR inhibitors are associated with undesirable adverse events, with some having a more manageable toxicity profile compared to others. As a result, choice of treatment poses a challenge for healthcare providers and patients. Nonetheless, these agents demonstrate improved disease/progression free survival (DFS/PFS) values and remain a critical component in the treatment of kidney cancer. |
| first_indexed | 2024-03-12T14:02:37Z |
| format | Article |
| id | doaj.art-44fef24712664f22bbacb1caf9e6f9ed |
| institution | Directory Open Access Journal |
| issn | 2088-4559 2477-0256 |
| language | English |
| last_indexed | 2024-03-12T14:02:37Z |
| publishDate | 2023-07-01 |
| publisher | Universitas Ahmad Dahlan |
| record_format | Article |
| series | Pharmaciana |
| spelling | doaj.art-44fef24712664f22bbacb1caf9e6f9ed2023-08-22T02:32:21ZengUniversitas Ahmad DahlanPharmaciana2088-45592477-02562023-07-0113221122310.12928/pharmaciana.v13i2.24638Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinomaJie Yi Tan0Aadya Jaipuria1Ronny Priefer2Massachusetts College of Pharmacy and Health Sciences UniversityMassachusetts College of Pharmacy and Health Sciences UniversityMassachusetts College of Pharmacy and Health Sciences UniversityVascular endothelial growth factors receptors (VEGFR) inhibitors play a vital role in the treatment of renal cell carcinoma. These are small molecules that predominantly exhibit anti-angiogenesis activity in conjunction with other anti-tumor effects. These drug therapies are approved for the use in patients as frontline agents or adjuvant therapy in renal cell carcinoma. However, VEGFR inhibitors are associated with undesirable adverse events, with some having a more manageable toxicity profile compared to others. As a result, choice of treatment poses a challenge for healthcare providers and patients. Nonetheless, these agents demonstrate improved disease/progression free survival (DFS/PFS) values and remain a critical component in the treatment of kidney cancer.http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/24638/pdf_283vegfr inhibitorsrenal cell carcinomakidney cancerprogression-free survivaladverse drug events |
| spellingShingle | Jie Yi Tan Aadya Jaipuria Ronny Priefer Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma Pharmaciana vegfr inhibitors renal cell carcinoma kidney cancer progression-free survival adverse drug events |
| title | Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma |
| title_full | Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma |
| title_fullStr | Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma |
| title_full_unstemmed | Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma |
| title_short | Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma |
| title_sort | comparison of small molecules vegfr inhibitors in the treatment of renal cell carcinoma |
| topic | vegfr inhibitors renal cell carcinoma kidney cancer progression-free survival adverse drug events |
| url | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/24638/pdf_283 |
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