Pharmacokinetic and parasitological evaluation of the bone marrow of dogs with visceral leishmaniasis submitted to multiple dose treatment with liposome-encapsulated meglumine antimoniate

Pharmacokinetic and parasitological evaluation of the bone marrow of dogs with visceral leishmaniasis submitted to multiple dose treatment with liposome-encapsulated meglumine antimoniate

The aim of the present study was to evaluate the impact of a multiple dose regimen of a liposomal formulation of meglumine antimoniate (LMA) on the pharmacokinetics of antimony in the bone marrow of dogs with visceral leishmaniasis and on the ability of LMA to eliminate parasites from this tissue. D...

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Bibliographic Details
Main Authors:	D.A. Schettini, A.P. Costa Val, L.F. Souza, C. Demicheli, O.G.F. Rocha, M.N. Melo, M.S.M. Michalick, F. Frézard
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2005-12-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Liposome Meglumine antimoniate Pharmacokinetics Leishmaniasis Dogs Bone marrow
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200017

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