Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model
Remyelination therapies, which are currently under development, have a great potential to delay, prevent or even reverse disability in multiple sclerosis patients. Several models are available to study the effectiveness of novel compounds in vivo, among which is the cuprizone model. This model is ch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/24/16093 |
| _version_ | 1797457192634286080 |
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| author | Heinig Leo Markus Kipp |
| author_facet | Heinig Leo Markus Kipp |
| author_sort | Heinig Leo |
| collection | DOAJ |
| description | Remyelination therapies, which are currently under development, have a great potential to delay, prevent or even reverse disability in multiple sclerosis patients. Several models are available to study the effectiveness of novel compounds in vivo, among which is the cuprizone model. This model is characterized by toxin-induced demyelination, followed by endogenous remyelination after cessation of the intoxication. Due to its high reproducibility and ease of use, this model enjoys high popularity among various research and industrial groups. In this review article, we will summarize recent findings using this model and discuss the potential of some of the identified compounds to promote remyelination in multiple sclerosis patients. |
| first_indexed | 2024-03-09T16:18:40Z |
| format | Article |
| id | doaj.art-45037235cd174f1abd5f4b98fd14612c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:18:40Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-45037235cd174f1abd5f4b98fd14612c2023-11-24T15:32:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241609310.3390/ijms232416093Remyelination in Multiple Sclerosis: Findings in the Cuprizone ModelHeinig Leo0Markus Kipp1Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, GermanyInstitute of Anatomy, Rostock University Medical Center, 18057 Rostock, GermanyRemyelination therapies, which are currently under development, have a great potential to delay, prevent or even reverse disability in multiple sclerosis patients. Several models are available to study the effectiveness of novel compounds in vivo, among which is the cuprizone model. This model is characterized by toxin-induced demyelination, followed by endogenous remyelination after cessation of the intoxication. Due to its high reproducibility and ease of use, this model enjoys high popularity among various research and industrial groups. In this review article, we will summarize recent findings using this model and discuss the potential of some of the identified compounds to promote remyelination in multiple sclerosis patients.https://www.mdpi.com/1422-0067/23/24/16093cuprizonemultiple sclerosisremyelinationdemyelinationprogressionprotection |
| spellingShingle | Heinig Leo Markus Kipp Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model International Journal of Molecular Sciences cuprizone multiple sclerosis remyelination demyelination progression protection |
| title | Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model |
| title_full | Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model |
| title_fullStr | Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model |
| title_full_unstemmed | Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model |
| title_short | Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model |
| title_sort | remyelination in multiple sclerosis findings in the cuprizone model |
| topic | cuprizone multiple sclerosis remyelination demyelination progression protection |
| url | https://www.mdpi.com/1422-0067/23/24/16093 |
| work_keys_str_mv | AT heinigleo remyelinationinmultiplesclerosisfindingsinthecuprizonemodel AT markuskipp remyelinationinmultiplesclerosisfindingsinthecuprizonemodel |