Three-Day Continuous Oxytocin Infusion Attenuates Thermal and Mechanical Nociception by Rescuing Neuronal Chloride Homeostasis via Upregulation KCC2 Expression and Function

Three-Day Continuous Oxytocin Infusion Attenuates Thermal and Mechanical Nociception by Rescuing Neuronal Chloride Homeostasis via Upregulation KCC2 Expression and Function

Oxytocin (OT) and its receptor are promising targets for the treatment and prevention of the neuropathic pain. In the present study, we compared the effects of a single and continuous intrathecal infusion of OT on nerve injury-induced neuropathic pain behaviours in mice and further explore the mecha...

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Bibliographic Details
Main Authors: Xiyuan Ba, Chenqiu Ran, Wenjun Guo, Jing Guo, Qian Zeng, Tao Liu, Wuping Sun, Lizu Xiao, Donglin Xiong, Yelan Huang, Changyu Jiang, Yue Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
neuropathic pain
oxytocin
chloride homeostasis
K+-Cl-cotransporter 2
continuous intrathecal drug delivery
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.845018/full

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