A New Parasitic Archamoeba Causing Systemic Granulomatous Disease in Goldfish Extends the Diversity of Pathogenic <i>Endolimax</i> spp.
<i>Endolimax</i> is a genus of intestinal amoebae which stands among the least known human protists. Previous studies on amoebic systemic granulomatosis of a marine fish (<i>Solea senegalensis</i>) resulted in the unexpected characterization of a new organism which was relate...
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MDPI AG
2023-03-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/5/935 |
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| author | Maria Constenla Oswaldo Palenzuela |
| author_facet | Maria Constenla Oswaldo Palenzuela |
| author_sort | Maria Constenla |
| collection | DOAJ |
| description | <i>Endolimax</i> is a genus of intestinal amoebae which stands among the least known human protists. Previous studies on amoebic systemic granulomatosis of a marine fish (<i>Solea senegalensis</i>) resulted in the unexpected characterization of a new organism which was related to <i>Endolimax</i> and named <i>E. piscium</i>. The existence of multiple reports of systemic granulomatosis caused presumptively by unidentified amoebae in goldfish lead us to investigate the organism involved in goldfish disease. Analysed goldfish presented small whitish nodules in the kidney, which correspond to chronic granulomatous inflammatory reactions with a ring-layer of amoebae in the periphery. Amoebae were amitochondriate and were located in a parasitophorous vacuole within macrophages, as previous studies on this condition in goldfish and other freshwater fish pointed out. SSU rDNA characterization confirmed a new <i>Endolimax</i> lineage which appears closely related to <i>E. piscium</i>, but the molecular evidence, distinct pathological features and lack of ecological overlapping between the hosts support their assignment to a new species, <i>E. carassius</i>. The results support the existence of a considerable unexplored diversity of <i>Endolimax</i> spp. among fish, and their proper characterization can contribute to an understanding of Archamoebae evolution and pathogenic potential. |
| first_indexed | 2024-03-11T07:31:41Z |
| format | Article |
| id | doaj.art-450777a27b124ccdbdd0973367458a5c |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T07:31:41Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-450777a27b124ccdbdd0973367458a5c2023-11-17T07:14:19ZengMDPI AGAnimals2076-26152023-03-0113593510.3390/ani13050935A New Parasitic Archamoeba Causing Systemic Granulomatous Disease in Goldfish Extends the Diversity of Pathogenic <i>Endolimax</i> spp.Maria Constenla0Oswaldo Palenzuela1Departament de Biologia Animal, de Biologia Vegetal i Ecologia and Servei de Diagnostic Patologic en Peixos, Universitat Autonoma de Barcelona (UAB), 08193 Barcelona, SpainInstituto de Acuicultura Torre de la Sal (IATS, CSIC), 12595 Ribera de Cabanes, Spain<i>Endolimax</i> is a genus of intestinal amoebae which stands among the least known human protists. Previous studies on amoebic systemic granulomatosis of a marine fish (<i>Solea senegalensis</i>) resulted in the unexpected characterization of a new organism which was related to <i>Endolimax</i> and named <i>E. piscium</i>. The existence of multiple reports of systemic granulomatosis caused presumptively by unidentified amoebae in goldfish lead us to investigate the organism involved in goldfish disease. Analysed goldfish presented small whitish nodules in the kidney, which correspond to chronic granulomatous inflammatory reactions with a ring-layer of amoebae in the periphery. Amoebae were amitochondriate and were located in a parasitophorous vacuole within macrophages, as previous studies on this condition in goldfish and other freshwater fish pointed out. SSU rDNA characterization confirmed a new <i>Endolimax</i> lineage which appears closely related to <i>E. piscium</i>, but the molecular evidence, distinct pathological features and lack of ecological overlapping between the hosts support their assignment to a new species, <i>E. carassius</i>. The results support the existence of a considerable unexplored diversity of <i>Endolimax</i> spp. among fish, and their proper characterization can contribute to an understanding of Archamoebae evolution and pathogenic potential.https://www.mdpi.com/2076-2615/13/5/935parasitesfisharchamoebaesystemic granulomatosis<i>Carassius auratus</i><i>Iodamoeba</i> |
| spellingShingle | Maria Constenla Oswaldo Palenzuela A New Parasitic Archamoeba Causing Systemic Granulomatous Disease in Goldfish Extends the Diversity of Pathogenic <i>Endolimax</i> spp. Animals parasites fish archamoebae systemic granulomatosis <i>Carassius auratus</i> <i>Iodamoeba</i> |
| title | A New Parasitic Archamoeba Causing Systemic Granulomatous Disease in Goldfish Extends the Diversity of Pathogenic <i>Endolimax</i> spp. |
| title_full | A New Parasitic Archamoeba Causing Systemic Granulomatous Disease in Goldfish Extends the Diversity of Pathogenic <i>Endolimax</i> spp. |
| title_fullStr | A New Parasitic Archamoeba Causing Systemic Granulomatous Disease in Goldfish Extends the Diversity of Pathogenic <i>Endolimax</i> spp. |
| title_full_unstemmed | A New Parasitic Archamoeba Causing Systemic Granulomatous Disease in Goldfish Extends the Diversity of Pathogenic <i>Endolimax</i> spp. |
| title_short | A New Parasitic Archamoeba Causing Systemic Granulomatous Disease in Goldfish Extends the Diversity of Pathogenic <i>Endolimax</i> spp. |
| title_sort | new parasitic archamoeba causing systemic granulomatous disease in goldfish extends the diversity of pathogenic i endolimax i spp |
| topic | parasites fish archamoebae systemic granulomatosis <i>Carassius auratus</i> <i>Iodamoeba</i> |
| url | https://www.mdpi.com/2076-2615/13/5/935 |
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