Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study
Abnormal spermatozoa can not only reduce the fertilization rate, but also prolong the natural conception time and even increase the risk of spontaneous miscarriage. Diabetes mellitus (DM) has become a major global health problem, and its incidence continues to rise, while affecting an increasing num...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1035338/full |
| _version_ | 1797991114777559040 |
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| author | Mengyuan Dai Mengyuan Dai Weijie Guo Weijie Guo San Zhu San Zhu Guidong Gong Mei Chen Zhuoling Zhong Zhuoling Zhong Junling Guo Junling Guo Yaoyao Zhang Yaoyao Zhang |
| author_facet | Mengyuan Dai Mengyuan Dai Weijie Guo Weijie Guo San Zhu San Zhu Guidong Gong Mei Chen Zhuoling Zhong Zhuoling Zhong Junling Guo Junling Guo Yaoyao Zhang Yaoyao Zhang |
| author_sort | Mengyuan Dai |
| collection | DOAJ |
| description | Abnormal spermatozoa can not only reduce the fertilization rate, but also prolong the natural conception time and even increase the risk of spontaneous miscarriage. Diabetes mellitus (DM) has become a major global health problem, and its incidence continues to rise, while affecting an increasing number of men in their reproductive years. Type 2 Diabetes Mellitus (T2DM), accounting for about 85-95% of DM, is closely related to the development of sperm. However, the exact association between T2DM and abnormal spermatozoa remains unclear. Herein, we designed a Two-sample Mendelian randomization (MR) study to explore the causal association between T2DM and abnormal spermatozoa risk in European population data which come from the GWAS summary datasets. We selected 9 single nucleotide polymorphisms (SNPs) of T2DM (exposure data) as instrumental variables (IVs), and then retrieved the suitable abnormal spermatozoa genome-wide association study (GWAS) data of European from Ieu Open GWAS Project database which includes 915 cases and 209,006 control as the outcome data. Our results indicate that strict T2DM might not result in a higher risk of abnormal spermatozoa genetically in Europeans (OR: 1.017, 95% confidence interval (CI): 0.771-1.342, p=0.902). Our findings demonstrate that only T2DM may not explain the relatively higher risk of abnormal spermatozoa in men with it in Europeans. In subsequent studies, more comprehensive and larger samples need to be studied to reveal the relationship and potential mechanism between T2DM and abnormal spermatozoa. |
| first_indexed | 2024-04-11T08:46:17Z |
| format | Article |
| id | doaj.art-4509bd582e434d60bc4fd5a0d0c86f6b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T08:46:17Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4509bd582e434d60bc4fd5a0d0c86f6b2022-12-22T04:33:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10353381035338Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization studyMengyuan Dai0Mengyuan Dai1Weijie Guo2Weijie Guo3San Zhu4San Zhu5Guidong Gong6Mei Chen7Zhuoling Zhong8Zhuoling Zhong9Junling Guo10Junling Guo11Yaoyao Zhang12Yaoyao Zhang13Department of Obstetrics and Gynecology of West China Second University Hospital, BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology of West China Second University Hospital, BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology of West China Second University Hospital, BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology of West China Second University Hospital, BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Obstetrics and Gynecology of West China Second University Hospital, BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Obstetrics and Gynecology of West China Second University Hospital, BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology of West China Second University Hospital, BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, ChinaState Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology of West China Second University Hospital, BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, ChinaAbnormal spermatozoa can not only reduce the fertilization rate, but also prolong the natural conception time and even increase the risk of spontaneous miscarriage. Diabetes mellitus (DM) has become a major global health problem, and its incidence continues to rise, while affecting an increasing number of men in their reproductive years. Type 2 Diabetes Mellitus (T2DM), accounting for about 85-95% of DM, is closely related to the development of sperm. However, the exact association between T2DM and abnormal spermatozoa remains unclear. Herein, we designed a Two-sample Mendelian randomization (MR) study to explore the causal association between T2DM and abnormal spermatozoa risk in European population data which come from the GWAS summary datasets. We selected 9 single nucleotide polymorphisms (SNPs) of T2DM (exposure data) as instrumental variables (IVs), and then retrieved the suitable abnormal spermatozoa genome-wide association study (GWAS) data of European from Ieu Open GWAS Project database which includes 915 cases and 209,006 control as the outcome data. Our results indicate that strict T2DM might not result in a higher risk of abnormal spermatozoa genetically in Europeans (OR: 1.017, 95% confidence interval (CI): 0.771-1.342, p=0.902). Our findings demonstrate that only T2DM may not explain the relatively higher risk of abnormal spermatozoa in men with it in Europeans. In subsequent studies, more comprehensive and larger samples need to be studied to reveal the relationship and potential mechanism between T2DM and abnormal spermatozoa.https://www.frontiersin.org/articles/10.3389/fendo.2022.1035338/fullT2DMabnormal spermatozoaSNPsMendelian randomizationGWAS |
| spellingShingle | Mengyuan Dai Mengyuan Dai Weijie Guo Weijie Guo San Zhu San Zhu Guidong Gong Mei Chen Zhuoling Zhong Zhuoling Zhong Junling Guo Junling Guo Yaoyao Zhang Yaoyao Zhang Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study Frontiers in Endocrinology T2DM abnormal spermatozoa SNPs Mendelian randomization GWAS |
| title | Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study |
| title_full | Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study |
| title_fullStr | Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study |
| title_full_unstemmed | Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study |
| title_short | Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study |
| title_sort | type 2 diabetes mellitus and the risk of abnormal spermatozoa a mendelian randomization study |
| topic | T2DM abnormal spermatozoa SNPs Mendelian randomization GWAS |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1035338/full |
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