Endemic parasitic disease - Expert group opinion for South Asia for solid-organ transplantation − Leishmaniasis, malaria, toxoplasmosis, filariasis, and strongyloidiasis
Although parasitic infections including malaria, leishmania, and toxoplasmosis contribute to a significant burden of the morbidity and mortality of global populations, they remain woefully understudied in solid-organ transplantation with recommendations mainly based on expert opinions. This paradox...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Indian Journal of Transplantation |
| Subjects: | |
| Online Access: | http://www.ijtonline.in/article.asp?issn=2212-0017;year=2022;volume=16;issue=5;spage=57;epage=62;aulast=Ramasubramanian |
| _version_ | 1811313215624183808 |
|---|---|
| author | Venkatasubramanian Ramasubramanian Rajendran Surendran Nitin Bansal Sowmya Sridharan Natarajan Gopalakrishnan Suba Guru Prasad Muhibur Rahman Shyam Bihri Bansal |
| author_facet | Venkatasubramanian Ramasubramanian Rajendran Surendran Nitin Bansal Sowmya Sridharan Natarajan Gopalakrishnan Suba Guru Prasad Muhibur Rahman Shyam Bihri Bansal |
| author_sort | Venkatasubramanian Ramasubramanian |
| collection | DOAJ |
| description | Although parasitic infections including malaria, leishmania, and toxoplasmosis contribute to a significant burden of the morbidity and mortality of global populations, they remain woefully understudied in solid-organ transplantation with recommendations mainly based on expert opinions. This paradox is due to the fact that the geographic prevalence of most of these infections is restricted to the developing world where priorities of care are different due to economic constraints. Limited availability of transplant programs where parasitic infections are endemic, challenges in diagnosis, re-activation or recrudescence of latent infections which may present at a later date, the lesser impact of these infections in the immune-suppressed host and limited availability of drugs used in the treatment of some of these infections may influence therapeutic interventions. In the Indian sub-continent, malaria, visceral leishmaniasis (VL), filariasis, strongyloidiasis, and toxoplasmosis are endemic. India contributes to 4% of the total global burden of cases of malaria and has the highest number of cases among the South Asian countries. VL is restricted to Bihar and West Bengal in India and liposomal amphotericin, the drug of choice is still prohibitively expensive. The impact of toxoplasmosis, filariasis, and strongyloidiasis in solid-organ transplant is still limited compared to other infections. Challenges are mainly related to donor screening and exclusion as applying western recommendations to these endemic infections may not be practical. Early diagnosis and appropriate therapy improve outcomes. |
| first_indexed | 2024-04-13T10:49:55Z |
| format | Article |
| id | doaj.art-450c7c38514e4fbf922508618f48a0c3 |
| institution | Directory Open Access Journal |
| issn | 2212-0017 2212-0025 |
| language | English |
| last_indexed | 2024-04-13T10:49:55Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Transplantation |
| spelling | doaj.art-450c7c38514e4fbf922508618f48a0c32022-12-22T02:49:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252022-01-01165576210.4103/ijot.ijot_117_21Endemic parasitic disease - Expert group opinion for South Asia for solid-organ transplantation − Leishmaniasis, malaria, toxoplasmosis, filariasis, and strongyloidiasisVenkatasubramanian RamasubramanianRajendran SurendranNitin BansalSowmya SridharanNatarajan GopalakrishnanSuba Guru PrasadMuhibur RahmanShyam Bihri BansalAlthough parasitic infections including malaria, leishmania, and toxoplasmosis contribute to a significant burden of the morbidity and mortality of global populations, they remain woefully understudied in solid-organ transplantation with recommendations mainly based on expert opinions. This paradox is due to the fact that the geographic prevalence of most of these infections is restricted to the developing world where priorities of care are different due to economic constraints. Limited availability of transplant programs where parasitic infections are endemic, challenges in diagnosis, re-activation or recrudescence of latent infections which may present at a later date, the lesser impact of these infections in the immune-suppressed host and limited availability of drugs used in the treatment of some of these infections may influence therapeutic interventions. In the Indian sub-continent, malaria, visceral leishmaniasis (VL), filariasis, strongyloidiasis, and toxoplasmosis are endemic. India contributes to 4% of the total global burden of cases of malaria and has the highest number of cases among the South Asian countries. VL is restricted to Bihar and West Bengal in India and liposomal amphotericin, the drug of choice is still prohibitively expensive. The impact of toxoplasmosis, filariasis, and strongyloidiasis in solid-organ transplant is still limited compared to other infections. Challenges are mainly related to donor screening and exclusion as applying western recommendations to these endemic infections may not be practical. Early diagnosis and appropriate therapy improve outcomes.http://www.ijtonline.in/article.asp?issn=2212-0017;year=2022;volume=16;issue=5;spage=57;epage=62;aulast=Ramasubramanianfilariasisleishmaniasismalariaparasitesolid-organ transplantsouth asiastrongyloidestoxoplasmosis |
| spellingShingle | Venkatasubramanian Ramasubramanian Rajendran Surendran Nitin Bansal Sowmya Sridharan Natarajan Gopalakrishnan Suba Guru Prasad Muhibur Rahman Shyam Bihri Bansal Endemic parasitic disease - Expert group opinion for South Asia for solid-organ transplantation − Leishmaniasis, malaria, toxoplasmosis, filariasis, and strongyloidiasis Indian Journal of Transplantation filariasis leishmaniasis malaria parasite solid-organ transplant south asia strongyloides toxoplasmosis |
| title | Endemic parasitic disease - Expert group opinion for South Asia for solid-organ transplantation − Leishmaniasis, malaria, toxoplasmosis, filariasis, and strongyloidiasis |
| title_full | Endemic parasitic disease - Expert group opinion for South Asia for solid-organ transplantation − Leishmaniasis, malaria, toxoplasmosis, filariasis, and strongyloidiasis |
| title_fullStr | Endemic parasitic disease - Expert group opinion for South Asia for solid-organ transplantation − Leishmaniasis, malaria, toxoplasmosis, filariasis, and strongyloidiasis |
| title_full_unstemmed | Endemic parasitic disease - Expert group opinion for South Asia for solid-organ transplantation − Leishmaniasis, malaria, toxoplasmosis, filariasis, and strongyloidiasis |
| title_short | Endemic parasitic disease - Expert group opinion for South Asia for solid-organ transplantation − Leishmaniasis, malaria, toxoplasmosis, filariasis, and strongyloidiasis |
| title_sort | endemic parasitic disease expert group opinion for south asia for solid organ transplantation leishmaniasis malaria toxoplasmosis filariasis and strongyloidiasis |
| topic | filariasis leishmaniasis malaria parasite solid-organ transplant south asia strongyloides toxoplasmosis |
| url | http://www.ijtonline.in/article.asp?issn=2212-0017;year=2022;volume=16;issue=5;spage=57;epage=62;aulast=Ramasubramanian |
| work_keys_str_mv | AT venkatasubramanianramasubramanian endemicparasiticdiseaseexpertgroupopinionforsouthasiaforsolidorgantransplantationleishmaniasismalariatoxoplasmosisfilariasisandstrongyloidiasis AT rajendransurendran endemicparasiticdiseaseexpertgroupopinionforsouthasiaforsolidorgantransplantationleishmaniasismalariatoxoplasmosisfilariasisandstrongyloidiasis AT nitinbansal endemicparasiticdiseaseexpertgroupopinionforsouthasiaforsolidorgantransplantationleishmaniasismalariatoxoplasmosisfilariasisandstrongyloidiasis AT sowmyasridharan endemicparasiticdiseaseexpertgroupopinionforsouthasiaforsolidorgantransplantationleishmaniasismalariatoxoplasmosisfilariasisandstrongyloidiasis AT natarajangopalakrishnan endemicparasiticdiseaseexpertgroupopinionforsouthasiaforsolidorgantransplantationleishmaniasismalariatoxoplasmosisfilariasisandstrongyloidiasis AT subaguruprasad endemicparasiticdiseaseexpertgroupopinionforsouthasiaforsolidorgantransplantationleishmaniasismalariatoxoplasmosisfilariasisandstrongyloidiasis AT muhiburrahman endemicparasiticdiseaseexpertgroupopinionforsouthasiaforsolidorgantransplantationleishmaniasismalariatoxoplasmosisfilariasisandstrongyloidiasis AT shyambihribansal endemicparasiticdiseaseexpertgroupopinionforsouthasiaforsolidorgantransplantationleishmaniasismalariatoxoplasmosisfilariasisandstrongyloidiasis |