Biomarkers for patients with trauma associated acute respiratory distress syndrome
Abstract Trauma is a major factor that contributes to the risk for acute respiratory distress syndrome (ARDS). Biomarkers that predict the risk, diagnosis, treatment response and prognosis of ARDS after trauma have been widely investigated. In addition to their applications in clinical diagnosis and...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | Military Medical Research |
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| Online Access: | http://link.springer.com/article/10.1186/s40779-017-0134-5 |
| _version_ | 1818545032205959168 |
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| author | Wujian Xu Yong Song |
| author_facet | Wujian Xu Yong Song |
| author_sort | Wujian Xu |
| collection | DOAJ |
| description | Abstract Trauma is a major factor that contributes to the risk for acute respiratory distress syndrome (ARDS). Biomarkers that predict the risk, diagnosis, treatment response and prognosis of ARDS after trauma have been widely investigated. In addition to their applications in clinical diagnosis and treatment, these biomarkers provide important insights into our understanding of the pathogenesis of ARDS. This review begins with a brief introduction regarding the incidence and pathogenesis of trauma-associated ARDS. Then, we focus on reviewing the clinical trials that have been designed to investigate the value of biomarkers in ARDS after trauma. Biomarkers with a confirmed value in ARDS have been organized on the basis of key pathogenic processes that are central to ARDS and are described in detail. Among these, angiopoietin 2 (Ang-2), L-selectin, Clara cell protein 16 (CC16), soluable receptor for advanced glycation end products (sRAGE), Surfactant protein D (SP-D), histones, mtDNAs and some biomarker panels had a certain association with the diagnosis and prognosis of trauma-related ARDS. Further investigations are needed regarding the design of trials, the best sampling approaches and the optimal combinations of the biomarker panels. |
| first_indexed | 2024-12-11T22:56:13Z |
| format | Article |
| id | doaj.art-450ce731905b4bf2920d2762df044c28 |
| institution | Directory Open Access Journal |
| issn | 2054-9369 |
| language | English |
| last_indexed | 2024-12-11T22:56:13Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Military Medical Research |
| spelling | doaj.art-450ce731905b4bf2920d2762df044c282022-12-22T00:47:15ZengBMCMilitary Medical Research2054-93692017-08-01411710.1186/s40779-017-0134-5Biomarkers for patients with trauma associated acute respiratory distress syndromeWujian Xu0Yong Song1Department of Respiratory Medicine, Jinling HospitalDepartment of Respiratory Medicine, Jinling HospitalAbstract Trauma is a major factor that contributes to the risk for acute respiratory distress syndrome (ARDS). Biomarkers that predict the risk, diagnosis, treatment response and prognosis of ARDS after trauma have been widely investigated. In addition to their applications in clinical diagnosis and treatment, these biomarkers provide important insights into our understanding of the pathogenesis of ARDS. This review begins with a brief introduction regarding the incidence and pathogenesis of trauma-associated ARDS. Then, we focus on reviewing the clinical trials that have been designed to investigate the value of biomarkers in ARDS after trauma. Biomarkers with a confirmed value in ARDS have been organized on the basis of key pathogenic processes that are central to ARDS and are described in detail. Among these, angiopoietin 2 (Ang-2), L-selectin, Clara cell protein 16 (CC16), soluable receptor for advanced glycation end products (sRAGE), Surfactant protein D (SP-D), histones, mtDNAs and some biomarker panels had a certain association with the diagnosis and prognosis of trauma-related ARDS. Further investigations are needed regarding the design of trials, the best sampling approaches and the optimal combinations of the biomarker panels.http://link.springer.com/article/10.1186/s40779-017-0134-5TraumaInjuryAcute respiratory distress syndromeBiomarkers |
| spellingShingle | Wujian Xu Yong Song Biomarkers for patients with trauma associated acute respiratory distress syndrome Military Medical Research Trauma Injury Acute respiratory distress syndrome Biomarkers |
| title | Biomarkers for patients with trauma associated acute respiratory distress syndrome |
| title_full | Biomarkers for patients with trauma associated acute respiratory distress syndrome |
| title_fullStr | Biomarkers for patients with trauma associated acute respiratory distress syndrome |
| title_full_unstemmed | Biomarkers for patients with trauma associated acute respiratory distress syndrome |
| title_short | Biomarkers for patients with trauma associated acute respiratory distress syndrome |
| title_sort | biomarkers for patients with trauma associated acute respiratory distress syndrome |
| topic | Trauma Injury Acute respiratory distress syndrome Biomarkers |
| url | http://link.springer.com/article/10.1186/s40779-017-0134-5 |
| work_keys_str_mv | AT wujianxu biomarkersforpatientswithtraumaassociatedacuterespiratorydistresssyndrome AT yongsong biomarkersforpatientswithtraumaassociatedacuterespiratorydistresssyndrome |