Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo

Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo

Mast cells reside on and near the cerebral vasculature, the predominant site of pneumococcal entry into the central nervous system (CNS). Although mast cells have been reported to be crucial in protecting from systemic bacterial infections, their role in bacterial infections of the CNS remained elus...

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Bibliographic Details
Main Authors: Johanna Fritscher, Daniel Amberger, Susanne Dyckhoff, Jan Philipp Bewersdorf, Ilias Masouris, Stefanie Voelk, Sven Hammerschmidt, Helga Maria Schmetzer, Matthias Klein, Hans-Walter Pfister, Uwe Koedel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
mast cell
bacterial meningitis
innate immunity
Streptococcus pneumoniae
mouse model
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00550/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00550/full

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