Assessing the fitness of a dual-antiviral drug resistant human influenza virus in the ferret model

A clinical influenza isolate with dual antiviral resistant mutations displays a moderate loss of viral fitness in ferrets compared to wild-type virus, suggesting widespread community transmission of this dual mutant is unlikely.

Bibliographic Details
Main Authors: Harry L. Stannard, Edin J. Mifsud, Steffen Wildum, Sook Kwan Brown, Paulina Koszalka, Takao Shishido, Satoshi Kojima, Shinya Omoto, Keiko Baba, Klaus Kuhlbusch, Aeron C. Hurt, Ian G. Barr
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04005-4