High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
The hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 1...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2009-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016 |
| _version_ | 1818420665107087360 |
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| author | Letícia Cruz Evelise Assumpção Sílvia Stanisçuaski Guterres Adriana Raffin Pohlmann |
| author_facet | Letícia Cruz Evelise Assumpção Sílvia Stanisçuaski Guterres Adriana Raffin Pohlmann |
| author_sort | Letícia Cruz |
| collection | DOAJ |
| description | The hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration. |
| first_indexed | 2024-12-14T12:58:04Z |
| format | Article |
| id | doaj.art-45102be3150649d884dc4730870672fb |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-14T12:58:04Z |
| publishDate | 2009-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-45102be3150649d884dc4730870672fb2022-12-21T23:00:30ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642009-01-013251170117410.1590/S0100-40422009000500016High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticlesLetícia CruzEvelise AssumpçãoSílvia Stanisçuaski GuterresAdriana Raffin PohlmannThe hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016hydrophilic drugsodium alendronatemicroparticles |
| spellingShingle | Letícia Cruz Evelise Assumpção Sílvia Stanisçuaski Guterres Adriana Raffin Pohlmann High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles Química Nova hydrophilic drug sodium alendronate microparticles |
| title | High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
| title_full | High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
| title_fullStr | High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
| title_full_unstemmed | High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
| title_short | High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles |
| title_sort | high encapsulation efficiency of sodium alendronate in eudragit s100 hpmc blend microparticles |
| topic | hydrophilic drug sodium alendronate microparticles |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016 |
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